Genetic and environmental influences on gambling disorder liability: a replication and combined analysis of two twin studies

Psychological Medicine
Christal N DavisMichael T Lynskey

Abstract

Gambling disorder (GD), recognized in Diagnostic and Statistical Manual of Mental Disorders, Version 5 (DSM-5) as a behavioral addiction, is associated with a range of adverse outcomes. However, there has been little research on the genetic and environmental influences on the development of this disorder. This study reports results from the largest twin study of GD conducted to date. Replication and combined analyses were based on samples of 3292 (mean age 31.8, born 1972-79) and 4764 (mean age 37.7, born 1964-71) male, female, and unlike-sex twin pairs from the Australian Twin Registry. Univariate biometric twin models estimated the proportion of variation in the latent GD liability that could be attributed to genetic, shared environmental, and unique environmental factors, and whether these differed quantitatively or qualitatively for men and women. In the replication study, when using a lower GD threshold, there was evidence for significant genetic (60%; 95% confidence interval (CI) 45-76%) and unique environmental (40%; 95% CI 24-56%), but not shared environmental contributions (0%; 95% CI 0-0%) to GD liability; this did not significantly differ from the original study. In the combined analysis, higher GD thresholds (such a...Continue Reading

References

Sep 1, 1987·The American Journal of Psychiatry·H R Lesieur, S B Blume
May 1, 1994·Behavior Genetics·M C NealeK S Kendler
Nov 1, 1993·Archives of General Psychiatry·K S Kendler
Jul 13, 2005·Archives of Neurology·M Leann DoddJ Eric Ahlskog
Dec 15, 2005·Clinical Psychology Review·Thomas M Piasecki
Nov 13, 2008·Molecular Psychiatry·UNKNOWN Psychiatric GWAS Consortium Steering Committee
Feb 13, 2009·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Wendy S SlutskeNicholas G Martin
Jul 28, 2009·Neuroscience and Biobehavioral Reviews·Ruth J van HolstAnna E Goudriaan
May 12, 2010·Archives of Neurology·Daniel WeintraubAnthony E Lang
Jun 10, 2010·Archives of General Psychiatry·Wendy S SlutskeNicholas G Martin
Jul 20, 2010·Psychometrika·Albert Satorra, Peter M Bentler
Jul 12, 2012·Addiction Biology·Penelope A LindWendy S Slutske
Aug 10, 2012·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Michael T LynskeyNicholas G Martin
Oct 20, 2012·Behavioural Brain Research·Ruud van den BosLeonie de Visser
Mar 27, 2013·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Wendy S SlutskeNicholas G Martin
Oct 19, 2013·Frontiers in Psychology·Damien BreversXavier Noël
Aug 19, 2014·Psychology of Addictive Behaviors : Journal of the Society of Psychologists in Addictive Behaviors·Jeanne E SavageNicholas G Martin
Aug 30, 2014·Psychological Medicine·B VerhulstK S Kendler
Jan 1, 2014·Perspectives on Psychological Science : a Journal of the Association for Psychological Science·Daniel J Simons
Nov 12, 2015·Current Directions in Psychological Science·Christopher F ChabrisDavid I Laibson
Jun 18, 2016·European Psychiatry : the Journal of the Association of European Psychiatrists·M LangK F Mann
May 10, 2017·Psychology of Addictive Behaviors : Journal of the Society of Psychologists in Addictive Behaviors·Serena M KingWilliam G Iacono
May 13, 2017·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Li-Shiun ChenUNKNOWN Genetics and Treatment Workgroup of the Society for Research on Nicotine and Tobacco (SRNT)
Sep 8, 2017·The American Journal on Addictions·Nicki A DowlingAlun C Jackson
Oct 4, 2017·The American Journal of Psychiatry·Patrick F SullivanUNKNOWN Psychiatric Genomics Consortium

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Citations

May 20, 2020·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Wendy S Slutske, Penelope A Lind
Sep 3, 2021·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Anna DochertyHilary Coon

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