Genetic and environmental influences on thyroid hormone variation in Mexican Americans

The Journal of Clinical Endocrinology and Metabolism
Paul B SamollowM Michael Barmada

Abstract

Thyroid hormones play major roles in the regulation of a wide range of metabolic and physiologic processes, but the genes and environmental factors that affect normal, quantitative variation in thyroid hormone concentrations are largely unknown. Using quantitative genetic methods, we evaluated the effects of genes and environmental factors on thyroid hormone variation in 586 women and 425 men from 27 randomly ascertained Mexican-American families from the San Antonio Family Heart Study. Data were available on free and total T(4), free and total T(3), TSH, thyroglobulin, and T(4)-binding globulin, as well as on covariates, including sex, age, weight, lifestyle habits, physical activity, and others. These covariates accounted for 2-18% of total phenotypic variation, whereas genes accounted for 26-64% of the variation. Overall, free T(3) had the highest heritability, which is noteworthy because it is the most biologically active thyroid hormone and accounts for the vast majority of metabolic and physiologic effects of thyroid hormones. Our results indicate that genes account for a substantial portion of variation in human thyroid hormone levels, and suggest that further studies to identify the genes involved in this variation coul...Continue Reading

Citations

Nov 15, 2012·Heredity·F Y AlulK K Ryckman
Sep 1, 2005·Thyroid : Official Journal of the American Thyroid Association·George G J M KuiperTheo J Visser
Oct 11, 2008·Thyroid : Official Journal of the American Thyroid Association·Helena Gásdal SørensenTheo J Visser
Nov 10, 2010·Thyroid : Official Journal of the American Thyroid Association·Laura BoucaiMartin I Surks
Oct 20, 2009·The Journal of Clinical Endocrinology and Metabolism·Gil AtzmonIlan Gabriely
Apr 2, 2013·Endocrine·Ioannis VasiliadisDennis V Cokkinos
May 24, 2014·Human Molecular Genetics·Ming ZhanUNKNOWN China Consortium for Genetics of Autoimmune Thyroid Disease
Oct 1, 2014·Thyroid : Official Journal of the American Thyroid Association·Jacqueline JonklaasUNKNOWN American Thyroid Association Task Force on Thyroid Hormone Replacement
Aug 19, 2007·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Faustino R Pérez-López
Jun 19, 2007·Best Practice & Research. Clinical Endocrinology & Metabolism·Wendy M van der DeureTheo J Visser
May 22, 2007·Archives of Gerontology and Geriatrics·Lilia Cárdenas-IbarraJesús Z Villarreal-Pérez
Aug 4, 2016·Thyroid : Official Journal of the American Thyroid Association·Layal ChakerRobin P Peeters
Mar 10, 2015·Endocrine Reviews·Marco MediciRobin P Peeters
Jul 10, 2008·The Journal of Clinical Endocrinology and Metabolism·Vijay PanickerJohn P Walsh
Nov 9, 2006·American Journal of Physiology. Endocrinology and Metabolism·Pia Skov HansenLaszlo Hegedüs
Dec 8, 2009·The Journal of Clinical Endocrinology and Metabolism·Martin I Surks, Laura Boucai
Jul 21, 2007·Endocrinology·Lars C MoellerRoy E Weiss
Jun 28, 2018·Endocrinology and Metabolism·Yul Hwangbo, Young Joo Park
Mar 3, 2019·Journal of Human Genetics·Ivana GunjačaMaja Barbalić
Jan 24, 2021·The Journal of Clinical Endocrinology and Metabolism·Nicole LafontaineScott G Wilson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.