Genetic and environmental influences underlying externalizing behaviors, cigarette smoking and illicit drug use across adolescence.

Behavior Genetics
Tellervo KorhonenAnja C Huizink

Abstract

We investigated genetic and environmental influences common to adolescent externalizing behavior (at age 12), smoking (at age 14) and initiation of drug use (at age 17) using the FinnTwin12 cohort data. Multivariate Cholesky models were fit to data from 737 monozygotic and 722 dizygotic twin pairs. Heritability of externalizing behavior was 56%, that of smoking initiation/amount 20/32%, and initiation of drug use 27%. In the best-fitting model common environmental influences explained most of the covariance between externalizing behavior and smoking initiation (69%) and amount (77%). Covariance between smoking initiation/amount and drug use was due to additive genetic (42/22%) and common environmental (58/78%) influences. Half of the covariance between externalizing behavior and drug use was due to shared genetic and half due to the environments shared by co-twins. Using a longitudinal, prospective design, our results indicate that early observed externalizing behavior provides significant underlying genetic and environmental influences common to later substance use, here manifested as initiation of drug use in late adolescence.

References

May 1, 1991·Journal of the American Academy of Child and Adolescent Psychiatry·J M Rey, A Morris-Yates
Jan 1, 1997·Journal of Personality and Social Psychology·D R Miles, G Carey
May 1, 1997·Alcoholism, Clinical and Experimental Research·J R KoopmansD I Boomsma
Mar 21, 2000·Twin Research : the Official Journal of the International Society for Twin Studies·L PulkkinenR J Rose
May 19, 2000·Neuroscience and Biobehavioral Reviews·L P Spear
Mar 23, 2002·Journal of Pediatric Psychology·Inka VaalamoRichard J Rose
May 28, 2002·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Minna HapponenRichard J Rose
Nov 5, 2002·Nature Reviews. Genetics·Dorret BoomsmaLeena Peltonen
Jan 23, 2003·Twin Research : the Official Journal of the International Society for Twin Studies·Jaakko KaprioRichard J Rose
May 2, 2003·Twin Research : the Official Journal of the International Society for Twin Studies·Lea PulkkinenRichard J Rose
Dec 10, 2003·Archives of General Psychiatry·Soo Hyun RheeMichael C Stallings
Jun 15, 2004·Twin Research : the Official Journal of the International Society for Twin Studies·Elina VierikkoRichard J Rose
Jul 22, 2004·Addiction·Satu K BarmanRichard J Rose
Sep 8, 2004·Archives of General Psychiatry·Brian M HicksChristopher J Patrick
Sep 1, 2005·Addiction·William A Vega, Andres G Gil
May 16, 2006·Addiction·Arpana Agrawal, Michael T Lynskey
Jun 14, 2006·Behavior Genetics·Michael C NealeKenneth S Kendler
Jun 16, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Ann S HamiltonThomas M Mack
Aug 11, 2006·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Michael C NealeKristen Jacobson
Jan 16, 2007·Pharmacology, Biochemistry, and Behavior·Fulton CrewsClyde Hodge
Jan 27, 2007·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Jaakko Kaprio
Feb 28, 2008·Social Psychiatry and Psychiatric Epidemiology·Mohammad Reza HayatbakhshRosa Alati
May 3, 2008·Pediatrics in Review·Eric HazenEugene Beresin
May 23, 2009·The American Journal of Drug and Alcohol Abuse·Levent KirisciSema Aytaclar
Mar 11, 2010·Journal of the American Academy of Child and Adolescent Psychiatry·Tellervo KorhonenAnja C Huizink
Dec 15, 2010·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Tellervo KorhonenAnja C Huizink
Jun 22, 2011·Alcoholism, Clinical and Experimental Research·Danielle M DickKenneth S Kendler

❮ Previous
Next ❯

Citations

Feb 20, 2014·Drug and Alcohol Dependence·Antti LatvalaJaakko Kaprio
Jul 13, 2013·The British Journal of Psychiatry : the Journal of Mental Science·Annabeth P GroenmanStephen V Faraone
Sep 27, 2012·Drug and Alcohol Dependence·Arpana AgrawalMichael T Lynskey
Apr 30, 2016·Journal of the American Academy of Child and Adolescent Psychiatry·Mary-Anne EnochDavid L Olds
Aug 27, 2013·Drug and Alcohol Dependence·Karin J H VerweijMichael T Lynskey
Jan 22, 2015·Behavior Genetics·Karoline Brobakke SeglemSvenn Torgersen
Nov 4, 2016·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Hermine H MaesMichael C Neale
Oct 24, 2019·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Richard J RoseJaakko Kaprio
Jan 19, 2021·Current Genetic Medicine Reports·Emma C JohnsonArpana Agrawal

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies
Tellervo KorhonenAnja C Huizink
Behavior Genetics
Jessica H BakerKenneth S Kendler
Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies
Tanya M M ButtonMichael C Stallings
© 2022 Meta ULC. All rights reserved