Genetic and environmental sources of covariation between generalized anxiety disorder and neuroticism

The American Journal of Psychiatry
John M HettemaKenneth S Kendler

Abstract

The authors examined the sources of covariation between generalized anxiety disorder and the personality trait of neuroticism. Because women have higher levels of neuroticism and twice the risk of lifetime generalized anxiety disorder of men, gender-specific effects were also explored. Lifetime generalized anxiety disorder and neuroticism were assessed in more than 8,000 twins from male-male, female-female, and opposite-sex pairs through structured diagnostic interviews. Sex-limited Cholesky structural equation models were used to decompose the correlations between generalized anxiety disorder and neuroticism into genetic and environmental components, including sex-specific factors. Genetic correlations between generalized anxiety disorder and neuroticism were high and differed (nonsignificantly) between men and women (1.00 and 0.58, respectively). When nonsignificant gender differences were removed from the models, correlations between generalized anxiety disorder and neuroticism were estimated at 0.80 (95% confidence interval=0.52-1.00). The individual-specific environmental correlation between generalized anxiety disorder and neuroticism was estimated at 0.20 for both genders. There is substantial overlap between the genetic...Continue Reading

Citations

Feb 26, 2008·European Archives of Psychiatry and Clinical Neuroscience·Alice M GregoryThalia C Eley
Dec 21, 2005·Behavior Genetics·Jan Fullerton
May 5, 2010·Behavior Genetics·Ragnhild Bang NesK Tambs
Mar 2, 2011·Clinical Child and Family Psychology Review·Sarah J Kertz, Janet Woodruff-Borden
Mar 12, 2013·Journal of Abnormal Child Psychology·Laura K HinkIrwin D Waldman
Aug 2, 2006·Current Psychiatry Reports·Mina Brandes, O Joseph Bienvenu
Dec 12, 2012·Journal of Molecular Neuroscience : MN·Nagesh AragamXuefeng Liu
Oct 23, 2008·Psychological Medicine·J M Murphy, A H Leighton
Oct 3, 2009·Psychological Medicine·D P GoldbergM J Hobbs
Apr 12, 2011·Psychological Medicine·K S Kendler, C O Gardner
Aug 30, 2006·Journal of Family Psychology : JFP : Journal of the Division of Family Psychology of the American Psychological Association (Division 43)·Marianne Z Wamboldt, David Reiss
Mar 9, 2011·Social Cognitive and Affective Neuroscience·Doreen M Olvet, Greg Hajcak
Oct 16, 2009·The Journal of Nervous and Mental Disease·Denise A ChaviraPeter P Roy-Byrne
Sep 30, 2009·The Australian Journal of Rural Health·Katharine E HeathcoteJohn R Beard
Mar 2, 2006·Genes, Brain, and Behavior·V CarolaC Gross
Nov 20, 2008·Annals of General Psychiatry·Dorte M Christiansen, Ask Elklit
Jul 17, 2010·PloS One·Federico C F CalboliDavid J Balding
Apr 14, 2006·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·David C RettewDorret I Boomsma
Jun 15, 2007·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Ragnhild B NesKristian Tambs
Jan 1, 2014·Psychiatry Research·David K MarcusPaul Kwon
Aug 15, 2013·Psychological Medicine·K Naragon-GaineyT A Brown
Dec 2, 2006·The British Journal of Psychiatry : the Journal of Mental Science·David M FergussonJoseph M Boden
Sep 16, 2015·International Journal of Environmental Research and Public Health·Marta Regina Cezar-VazMara Regina Santos da Silva
Feb 23, 2008·Annals of Medicine·Iiris Hovatta, Carrolee Barlow
Nov 20, 2013·Psychological Reports·Ahmed M Abdel-Khalek
Nov 26, 2009·European Psychiatry : the Journal of the Association of European Psychiatrists·L PoustkaJ Miettunen
May 26, 2009·Journal of Anxiety Disorders·Douglas S MenninThomas J Flanagan
Feb 26, 2008·Hormones and Behavior·Audrey R TyrkaLinda L Carpenter
Dec 18, 2007·Biological Psychiatry·Janice M FullertonJonathan Flint
Dec 1, 2007·Journal of the American Academy of Child and Adolescent Psychiatry·Denise A ChaviraMurray B Stein
Apr 24, 2007·Journal of the American Academy of Child and Adolescent Psychiatry·Chiara A M SpatolaMarco Battaglia
Apr 17, 2008·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·John M Hettema

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