Genetic and epigenetic associations to obesity-related appetite phenotypes among African-American children

Pediatric Obesity
K R GardnerJennifer O Fisher

Abstract

Genetic and epigenetic variations may be an important contributer to altered eating behaviors in childhood which may lead to weight gain and obesity later in life. This study aimed to evaluate epigenetic as well as genetic associations with appetite in young children. Participants were 32 non-obese and 32 obese African-American children aged 5-6 years. Saliva was collected from each child, and RNA and DNA were extracted for analysis. Individuals were genotyped for eating- and obesity-associated single nucleotide polymorphisms in seven candidate genes (FTO, MAOA, SH2B1, LEPR, DNMT3B, BDNF and CCKAR), and DNA methylation levels were measured in the upstream promoter region of each. Transcript levels of MAOA and FTO were also assessed. The Children's Eating Behavior Questionnaire (CEBQ) was used to assess the aspects of appetite. Child obesity was assessed using measured height and weight, and percent body fat was measured by dual-energy X-ray absorptiometry. Food responsiveness was higher and satiety responsiveness was lower among obese than non-obese female children (P = 0.001 and P = 0.031), but did not differ among male children. Epigenetic analysis of the BDNF promoter revealed associations with altered satiety responsiveness...Continue Reading

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Citations

Dec 17, 2016·Epigenomics·Sarah S ParkCathrine Hoyo
Oct 5, 2017·Human Molecular Genetics·Charles N RotimiAdebowale Adeyemo
Jun 19, 2018·Epigenetics : Official Journal of the DNA Methylation Society·Shota NishitaniAlicia K Smith
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Apr 19, 2019·JPEN. Journal of Parenteral and Enteral Nutrition·Michael SkinnerPeter F Nichol
Nov 12, 2019·Journal of Cellular Biochemistry·Rafael Silva LimaPaula Rocha Moreira
Sep 19, 2020·International Journal of Molecular Sciences·Mojgan GharipourShayesteh Jahanfar
Feb 9, 2021·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Alice KininmonthClare Llewellyn
Apr 17, 2016·Appetite·Karina Silva GarciaSheryl O Hughes

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