Genetic and epigenetic changes in rat preneoplastic liver tissue induced by 2-acetylaminofluorene.

Carcinogenesis
Tetyana V BagnyukovaIgor P Pogribny

Abstract

Genotoxic carcinogens, including 2-acetylaminofluorene (2-AAF), in addition to exerting their genotoxic effects, often cause a variety of non-genotoxic alterations in cells. It is believed that these non-genotoxic effects may be indispensable events in tumorigenesis; however, there is insufficient knowledge to clarify the role of carcinogens in both the genetic and epigenetic changes in premalignant tissues and a lack of conclusive information on the link between epigenetic alterations and carcinogenic exposure. In the current study, we investigated whether or not the mechanism of 2-AAF-induced hepatocarcinogenesis consists of both genotoxic (genetic) and non-genotoxic (epigenetic) alterations. Male and female Sprague-Dawley rats were fed NIH-31 diet containing 0.02% of 2-AAF for 6, 12, 18 or 24 weeks. The levels of DNA adducts obtained from 2-AAF in liver and kidney tissues were assessed by high-performance liquid chromatography combined with electrospray tandem mass spectrometry (HPLC-ES-MS/MS). N-(Deoxyguanosine-8-yl)-2-aminofluorene was the major adduct detected at all time points in both tissues. Global DNA methylation in the livers and kidneys, as determined by an HpaII-based cytosine extension assay and by HPLC-ES-MS/MS,...Continue Reading

References

Jan 1, 1990·General Pharmacology·G K Chambers
Mar 1, 1981·Chemico-biological Interactions·M S Lee, C M King
Jul 1, 1984·Biochemical Pharmacology·W Lilienblum, K W Bock
Oct 1, 1994·Environmental Health Perspectives·H G NeumannA Bitsch
Mar 1, 1997·Molecular and Cellular Biology·D S SwaffordS A Belinsky
Aug 1, 1997·Trends in Genetics : TIG·J A YoderT H Bestor
Sep 2, 1999·Biochemical and Biophysical Research Communications·I PogribnyS J James
Jan 27, 2000·Cell·D Hanahan, R A Weinberg
Mar 29, 2000·Environmental and Molecular Mutagenesis·D H PhillipsK W Turteltaub
May 2, 2000·Toxicological Sciences : an Official Journal of the Society of Toxicology·A BitschH G Neumann
Oct 29, 2002·International Journal of Cancer. Journal International Du Cancer·Mariko MurataShosuke Kawanishi
Dec 31, 2002·Toxicology·R A RobertsN Macdonald
Jan 9, 2004·Advances in Cancer Research·Lionel F Jaffe
Mar 16, 2004·Science·Haig H Kazazian
Apr 20, 2004·Toxicology Letters·Vincent BombailGeorge Orphanides
May 7, 2004·Journal of Cell Science·Niki KourmouliPrim B Singh
Aug 4, 2004·Cancer Research·Michele CarboneMay Wong
Oct 19, 2004·Seminars in Cancer Biology·Michele CarboneMay Wong
Oct 19, 2004·Seminars in Cancer Biology·Andrew P Feinberg
Jan 29, 2005·The EMBO Journal·Joost H A MartensThomas Jenuwein
Mar 8, 2005·Nature Cell Biology·Susana GonzaloMaría A Blasco
Dec 14, 2005·Liver International : Official Journal of the International Association for the Study of the Liver·Kenichi FukaiHiromitsu Saisho
Dec 21, 2005·Genome Research·Robert A RollinsTimothy H Bestor
Dec 22, 2005·Cancer Science·Toru FurukawaAkira Horii
Jan 21, 2006·Cancer Research·Kam-Wing JairKornel E Schuebel
Feb 3, 2006·International Journal of Cancer. Journal International Du Cancer·Eri AraiSetsuo Hirohashi
Apr 25, 2006·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Mariana Villarroel DorregoA William Barrett
Jul 22, 2006·The FEBS Journal·Thomas Jenuwein
Dec 22, 2006·The Journal of Nutrition·Igor P PogribnySharon A Ross
Jan 16, 2007·Molecular Carcinogenesis·Volodymyr P TryndyakIgor P Pogribny

❮ Previous
Next ❯

Citations

Sep 27, 2012·Cancer Letters·Igor P Pogribny, Frederick A Beland
Apr 26, 2011·Oncogene·J FüllgrabeB Joseph
Nov 1, 2011·Antioxidants & Redox Signaling·Igor KoturbashIgor P Pogribny
Mar 3, 2010·Mutagenesis·Eugenia CordelliRiccardo Crebelli
Jul 26, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Svitlana I ShpylevaIgor P Pogribny
Dec 15, 2010·Environmental Health Perspectives·Igor KoturbashIvan Rusyn
Dec 1, 2009·Epigenomics·Igor P Pogribny
Aug 16, 2014·Toxicology·Aline de ContiIgor P Pogribny
Sep 12, 2013·Toxicology and Industrial Health·Omolola A AdesanoyeEbenezer O Farombi
Dec 3, 2015·World Journal of Biological Chemistry·Shafqat Ali KhanSanjay Gupta
Sep 28, 2018·Food & Function·Nisha Susan ThomasAthavan Alias Anand Selvam
Feb 8, 2019·Molecular Nutrition & Food Research·Zahira Fernández-BedmarSilvia Guil-Luna
Jun 1, 2013·Journal of Toxicologic Pathology·Kohei MatsushitaTakashi Umemura
Apr 30, 2017·Experimental & Molecular Medicine·Kwangbeom HyunJaehoon Kim
Mar 26, 2021·Molecular Carcinogenesis·María Paulette Castro-GilJulio Isael Pérez-Carreón

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Epigenetics & Methyl-CpG (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. Here is the latest research on cancer epigenetics and methyl-CpG binding proteins including ZBTB38.

Cancer Epigenetics

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. Here is the latest research on cancer epigenetics.

Cell Signaling & Cancer Epigenetics (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. This feed covers the latest research on signaling and epigenetics in cell growth and cancer.

Cancer Epigenetics (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. Here is the latest research on cancer epigenetics.

Cancer Epigenetics & Metabolism (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. This feed focuses on the relationship between cell metabolism, epigenetics and tumor differentiation.

Cancer Epigenetics and Senescence (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may be involved in regulating senescence in cancer cells. This feed captures the latest research on cancer epigenetics and senescence.