Genetic and epigenetic characteristics of gastric cancers with JC virus T-antigen.

World Journal of Gastroenterology : WJG
Satoshi YamaokaYasuhisa Shinomura

Abstract

To clarify the significance of JC virus (JCV) T-antigen (T-Ag) expression in human gastric cancer. We investigated the relationship between T-Ag detected by immunohistochemistry and Epstein-Barr virus (EBV) infection, microsatellite instability (MSI), and genetic and epigenetic alterations in gastric cancers. Mutations in the p53, beta-catenin, KRAS, BRAF, PIK3CA genes were analyzed by polymerase chain reaction (PCR)-single strand conformation polymorphism and DNA sequencing. Allelic losses were determined by PCR at 7 microsatellite loci. Aberrant DNA methylation was analyzed by MethyLight assay. JCV T-Ag protein expression was found in 49% of 90 gastric cancer tissues. T-Ag positivity was not correlated with clinicopathological characteristics. T-Ag expression was detected in a similar percentage of EBV positive cancers (4 of 9, 44%) and EBV negative cancers (35 of 73, 48%). T-Ag expression was detected in a significantly lower percentage of MSI-H cancers (14%) than in non MSI-H cancers (55%, P = 0.005). T-Ag expression was detected in a significantly higher percentage of cancers with nuclear/cytoplasmic localization of beta-catenin (15 of 21, 71%) than in cancers without (42%, P = 0.018). p53 mutations were detected in a sign...Continue Reading

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Citations

Jul 27, 2012·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Alejandro A GruAndres A Roma
Jan 25, 2013·Gastroenterology Research and Practice·Jin Su KimYun Kyung Lee
Jun 21, 2013·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Hans H HirschCeline Leboeuf
Jul 10, 2014·Gut Microbes·Lindsay D ButcherC Richard Boland
Mar 14, 2013·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A F C OkinesA Wotherspoon
Aug 5, 2018·Journal of Cellular Physiology·Sadegh FattahiHaleh Akhavan-Niaki
Aug 24, 2019·Frontiers in Oncology·Luis Del Valle, Sergio Piña-Oviedo
May 1, 2021·Cancers·Manikandan PalrasuAlexander I Zaika

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