Genetic and epigenetic regulation of IgH gene assembly

Current Opinion in Immunology
Ranjan Sen, Eugene M Oltz

Abstract

Precursor B cells assemble a diverse repertoire of immunoglobulin (Ig) genes by the process of V(D)J recombination. Assembly of IgH genes is regulated in a tissue- and stage-specific manner via the activation and then the inactivation of distinct regions within the one megabase IgH locus. Recent studies have shown that regional control is achieved using a combination of genetic and epigenetic strategies, which modulate chromatin accessibility to V(D)J recombinase, relocate IgH loci within the nucleus, and promote changes in locus conformation that alter the spatial proximity of target gene segments. Orchestration of these regulatory processes is crucial for the generation of a functional B cell repertoire.

References

Mar 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·T E CostaM C Nussenzweig
Feb 1, 1991·International Immunology·J IacominiT Imanishi-Kari
Feb 13, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·L NitschkeJ Pelkonen
Nov 15, 2001·The EMBO Journal·D Chowdhury, R Sen
Jul 6, 2002·Science·Ingvild MikkolaMeinrad Busslinger
Jan 7, 2003·Genes & Development·David G T HessleinDavid G Schatz
Jan 18, 2003·Proceedings of the National Academy of Sciences of the United States of America·Yoshiko AkamatsuMarjorie A Oettinger
Jun 28, 2003·Nature Immunology·Michael S Krangel
Sep 23, 2003·Proceedings of the National Academy of Sciences of the United States of America·Katrina B MorsheadMarjorie A Oettinger
Dec 12, 2003·Nature Reviews. Immunology·Mark S Schlissel
Mar 10, 2004·The Journal of Experimental Medicine·Lih-Yun HsuMark S Schlissel
Mar 17, 2004·Current Opinion in Immunology·Dipanjan Chowdhury, Ranjan Sen
Apr 27, 2004·Nature Immunology·Daniel J BollandAnne E Corcoran
Jun 1, 2004·Proceedings of the National Academy of Sciences of the United States of America·Timur M Yusufzai, Gary Felsenfeld
Jul 10, 2004·Immunological Reviews·Dipanjan Chowdhury, Ranjan Sen
Jul 20, 2004·Nature Immunology·Kristen JohnsonKathryn Calame
Aug 26, 2004·Nucleic Acids Research·Sadiqur R TalukderYoshiko Akamatsu
Feb 3, 2005·Genes & Development·Camil E SayeghCornelis Murre
Mar 16, 2005·The Journal of Experimental Medicine·Sheila DiasPaulo Vieira
Jul 1, 2005·Molecular and Cellular Biology·Qiaoxin YangCarl L Schildkraut
Sep 28, 2005·Proceedings of the National Academy of Sciences of the United States of America·Thomas PerlotEric Pinaud
Feb 4, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Roshi AfsharEugene M Oltz

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Citations

Aug 18, 2010·Immunogenetics·Robert L SchelonkaHarry W Schroeder
Sep 6, 2007·The Journal of Experimental Medicine·John D CurryMark S Schlissel
Apr 2, 2008·Molecular and Cellular Biology·Vikrant Singh, Madhulika Srivastava
Dec 31, 2008·PloS One·W Jason CummingsNancy Maizels
Aug 23, 2011·Trends in Immunology·Ananda L RoyRobert G Roeder
Apr 11, 2008·Current Opinion in Immunology·Howard Cedar, Yehudit Bergman
Sep 16, 2008·European Journal of Immunology·Craig H BassingFrederick W Alt
Mar 17, 2007·Nature Reviews. Genetics·R Keith Slotkin, Robert Martienssen
Sep 7, 2007·The EMBO Journal·Janssen DalyInga-Lill Mårtensson
Apr 2, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Guillaume CheminLaurent Delpy
Jan 27, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Suchita HodawadekarMichael L Atchison
Jun 21, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lance R ThomasEugene M Oltz
Mar 25, 2009·International Journal of Immunopathology and Pharmacology·D FrezzaI A Rubino
May 21, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Igor I KuzinAndrea Bottaro
Oct 20, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Andre M ValeHarry W Schroeder
Jun 23, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lenka YunkEline T Luning Prak
Jun 17, 2006·Genes & Development·Mark S SchlisselJohn D Curry

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