Genetic and functional analysis of single nucleotide polymorphisms in the beta2-neuronal nicotinic acetylcholine receptor gene (CHRNB2)

Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco
Kira K LuedersDean H Hamer

Abstract

The beta2-neuronal nicotinic acetylcholine receptor gene (CHRNB2) is a logical candidate for influencing smoking behavior and nicotine dependence. We discovered six single nucleotide polymorphisms (SNPs) in the CHRNB2 gene by surveying 15.4 kb of genomic sequence including a previously undescribed 3' untranslated region that extends 4.0 kb downstream of the coding region. One of the SNPs causes an amino acid substitution in exon 5, one occurs in the promoter region, one changes an intronic base, and three occur in the 3' untranslated region. The ethnically dependent allele frequencies and the marker-to-marker linkage disequilibrium patterns of five of these polymorphisms were determined. The SNPs were assayed in 743 individuals for whom information on smoking history and lifelong nicotine dependence was available. No significant associations of the individual markers or their haplotypes to smoking behavior or level of nicotine dependence were found.

Citations

Mar 17, 2006·Current Psychiatry Reports·Ming D Li
Dec 4, 2003·Pharmacology, Biochemistry, and Behavior·M Dadmarz, W H Vogel
Aug 26, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jennifer WesselAndrew W Bergen
Jan 17, 2007·The Pharmacogenomics Journal·M K Ho, R F Tyndale
May 25, 2011·The Pharmacogenomics Journal·G E SwanA W Bergen
Jul 3, 2008·Human Molecular Genetics·David V ContiUNKNOWN Pharmacogenetics of Nicotine Addiction and Treatment Consortium
Jan 9, 2010·Annual Review of Pharmacology and Toxicology·Jibran Y KhokharRachel F Tyndale
Sep 17, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Kenneth A PerkinsJessica L Briski
May 16, 2009·Drug and Alcohol Dependence·George R UhlQing-Rong Liu
Jul 5, 2008·Behavioural Brain Research·Riju RayCaryn Lerman
Dec 6, 2007·American Journal of Preventive Medicine·Caryn E LermanMarcus R Munafò
Mar 5, 2009·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Nancy L SacconeLaura J Bierut
Jan 18, 2007·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Marissa A EhringerJoanna S Zeiger
Jan 1, 2008·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Daniel F HeitjanCaryn Lerman
Jan 29, 2013·Genes, Brain, and Behavior·H M KamensM A Ehringer
Oct 28, 2009·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Ming D LiJennie Z Ma
Sep 18, 2009·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Marissa A EhringerLaura J Bierut
Jul 17, 2007·Biochemical Pharmacology·Yann S Mineur, Marina R Picciotto
Oct 7, 2004·The Medical Clinics of North America·Susan M ZbikowskiJennifer B McClure
Jun 7, 2008·Biological Psychiatry·Ming D LiRobert C Elston
Feb 3, 2015·Progress in Neuro-psychopharmacology & Biological Psychiatry·Iren CsalaJudit Lazary
Aug 25, 2015·Current Addiction Reports·Darlene H BrunzellClaire I Dixon
Jun 21, 2006·Journal of Psychopharmacology·Anna M Lee, Rachel F Tyndale
Mar 1, 2005·Clinical Pharmacology and Therapeutics·Viba MalaiyandiRachel F Tyndale
Jan 13, 2006·Therapeutic Drug Monitoring·Nael Al Koudsi, Rachel F Tyndale
Mar 6, 2004·Pharmacological Reviews·Shelli L Kirstein, Paul A Insel
Dec 14, 2004·Substance Use & Misuse·Christina N LessovCaryn Lerman

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.