Genetic and genomic approaches to the detection of heart transplant rejection

Personalized Medicine
Evan P Kransdorf, Jon A Kobashigawa

Abstract

Since Christiaan Barnard performed the first heart transplant in 1967, over 100,000 heart transplants have been performed worldwide. As was true then, rejection remains the major threat to the function and survival of the allograft. The development of the endomyocardial biopsy as a means to monitor for rejection has allowed heart transplantation to thrive as a therapy for patients with end-stage heart disease. The need for a noninvasive method of rejection surveillance led to the development of the first genetic test for allograft rejection, the AlloMap®. In this article, after presenting the pathological and clinical features of cardiac allograft rejection, the authors discuss the development and application of gene-expression testing for the detection of cardiac allograft rejection. We then explore emerging 'omic' approaches that will be the rejection detection methods of the future.

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Citations

Jun 2, 2020·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Jean-Paul Duong Van HuyenGerald J Berry
May 12, 2018·Personalized Medicine·Evan P Kransdorf, Jon A Kobashigawa
Feb 5, 2014·Immunotherapy·David H ChangJon A Kobashigawa
Jan 9, 2021·Annales de pathologie·Marion RabantJean-Paul Duong-Van-Huyen
Jan 15, 2021·Indian Journal of Thoracic and Cardiovascular Surgery : Official Organ, Association of Thoracic and Cardiovascular Surgeons of India·Mahendra Narain Mishra

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Methods Mentioned

BETA
biopsy
biopsies
PCR
protein array
immunoprecipitation
electrophoresis

Software Mentioned

EIMAGE
IMAGE
CARGO
AlloMap

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