Genetic and Histopathological Responses to Cadmium Toxicity in Rabbit's Kidney and Liver: Protection by Ginger (Zingiber officinale)

Biological Trace Element Research
Ahmed A Baiomy, Ahmed A Mansour

Abstract

This study aimed to examine the protective effects of ginger (G) on the genetic response induced by cadmium (Cd) and immunohistochemical expression of Caspase3 and MKI67 in the kidney and liver of rabbits. Male rabbits were divided into three groups; each group contains 10 animals: group (C) received basic diet and tap water for 12 weeks, the second group (Cd) received 200 mg/kg b.w CdCl2 in water for 12 weeks, group (Cd + G) was given 200 mg/kg b.w CdCl2 in water and 400 mg ginger/kg b.w in food for 12 weeks. Cd administration increased the activity of mRNA expression of the examined apoptotic (Caspase3), proliferation (MKI67), proto-oncogene (C-fos), and antioxidant (GST), while decreased the expression of anti-apoptotic (Bcl2). Ginger counteracted the effects of Cd in (Cd + G) group and downregulated the previously upregulated genes under Cd administration appeared in (Cd) group. The immunohistochemical expression of Caspase3 and MKI67 in the liver and kidney cells of the (C) group was shown very faint to negative reactions, strong staining in hepatocytes and the tubular epithelium in cadmium-treated group, while slight staining in some hepatocytes and tubular epithelium in co-administration with ginger in (Cd + G) group. In...Continue Reading

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Citations

Jan 26, 2016·International Journal of Molecular Sciences·Adolf Michael Sandbichler, Martina Höckner
Sep 15, 2018·Journal of Applied Toxicology : JAT·Magdalena Mężyńska, Malgorzata M Brzóska
Aug 20, 2019·Journal of the Chinese Medical Association : JCMA·Yi-Shin Huang
May 30, 2020·International Journal of Environmental Research and Public Health·Giuseppe GenchiAlessia Catalano
Jul 15, 2017·Environmental Science and Pollution Research International·Rong-Kun BaoXin-Yue Wang
Apr 25, 2017·Toxicology Research·Zhongyu LiJianhua Qin
Dec 13, 2017·Environmental Science and Pollution Research International·Magdalena Mezynska, Malgorzata M Brzóska
Jan 7, 2019·Environmental Science and Pollution Research International·Asmaa F KhafagaMahmoud Alagawany
Nov 7, 2019·Journal of the Chinese Medical Association : JCMA·Yi-Shin Huang

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