Genetic and immunological factors interact in a mouse model of CNS antiphospholipid syndrome

Behavioural Brain Research
Aviva KatzavJoab Chapman

Abstract

The antiphospholipid syndrome (APS) includes systemic and central nervous system (CNS) pathology associated with antibodies to a complex of phospholipids and beta(2)-glycoprotein I (beta(2)-GPI). We have recently reported the induction of APS associated with behavioral and cognitive deficits in BALB/c female mice that developed 4-5 months after immunization with beta(2)-GPI. In the present study, we examined the influence of genetic factors on the ability to induce experimental APS with CNS involvement by testing several mouse strains immunized with beta(2)-GPI. Female mice from five strains were immunized once with beta(2)-GPI in complete Freund's adjuvant (CFA) or with CFA alone (controls). Autoantibody levels were examined at 1 and 5 months after immunization. Neurological assessment in a staircase test was performed 4-5 months following the immunization. Induction of APS resulted in elevated levels of antibodies against negatively charged phospholipids and beta(2)-GPI in all five mouse strains. Autoantibody levels were significantly higher in Balb/c, ICR, and C57BL/6 mouse strains compared to AKR and C3H. aPL levels dropped significantly more in the C57BL/6 compared to Balb/c mice over a period of 4 months. Hyperactivity re...Continue Reading

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Citations

Jun 27, 2009·Clinical Reviews in Allergy & Immunology·Aviva KatzavJoab Chapman
Jan 6, 2012·Clinical Rheumatology·Simone AppenzellerYehuda Shoenfeld
Jul 15, 2009·Seminars in Arthritis and Rheumatism·Yoav ArnsonHoward Amital
Sep 18, 2007·Journal of Neuroimmunology·Deborah K SokolJohn A McIntyre
Sep 18, 2009·Annals of the New York Academy of Sciences·Assaf MenachemAviva Katzav
Aug 26, 2006·Clinical Neurology and Neurosurgery·Penka A Atanassova, Borislav D Dimitrov
Aug 26, 2014·Journal of Autoimmunity·Aviva KatzavJoab Chapman
Jul 4, 2016·Journal of Autoimmunity·R WeissJ Chapman

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