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Genetic and immunopathological analysis of CHCHD10 in Australian amyotrophic lateral sclerosis and frontotemporal dementia and transgenic TDP-43 mice

Journal of Neurology, Neurosurgery, and Psychiatry

Nov 5, 2019

Emily P. McCannShu Yang

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Abstract

Since the first report of CHCHD10 gene mutations in amyotrophiclateral sclerosis (ALS)/frontotemporaldementia (FTD) patients, genetic variation in CHCHD10 has been inconsistently linked to disease. A pathological assessment of the CHCHD10 protein in patient neuronal tissue also remains ...read more

Mentioned in this Paper

Amyotrophic Lateral Sclerosis
Western Blotting
Brain
Cerebral Cortex
DNA-Binding Proteins
Frontal Lobe
Immunohistochemistry
Kidney Failure, Chronic
Laboratory mice
Mice, Transgenic
23
1
1
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Genetic and immunopathological analysis of CHCHD10 in Australian amyotrophic lateral sclerosis and frontotemporal dementia and transgenic TDP-43 mice

Journal of Neurology, Neurosurgery, and Psychiatry

Nov 5, 2019

Emily P. McCannShu Yang

PMID: 31690696

DOI: 10.1136/jnnp-2019-321790

Abstract

Since the first report of CHCHD10 gene mutations in amyotrophiclateral sclerosis (ALS)/frontotemporaldementia (FTD) patients, genetic variation in CHCHD10 has been inconsistently linked to disease. A pathological assessment of the CHCHD10 protein in patient neuronal tissue also remains ...read more

Mentioned in this Paper

Amyotrophic Lateral Sclerosis
Western Blotting
Brain
Cerebral Cortex
DNA-Binding Proteins
23
1
1

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