Genetic and Metabolite Variability in One-Carbon Metabolism Applied to an Insulin Resistance Model in Patients With Schizophrenia Receiving Atypical Antipsychotics.

Frontiers in Psychiatry
Kristen M WardVicki L Ellingrod

Abstract

Background: Patients with schizophrenia are at high risk of pre-mature mortality due to cardiovascular disease (CVD). Our group has completed studies in pharmacogenomics and metabolomics that have independently identified perturbations in one-carbon metabolism as associated with risk factors for CVD in this patient population. Therefore, this study aimed to use genetic and metabolomic data to determine the relationship between folate pharmacogenomics, one-carbon metabolites, and insulin resistance as measured using the homeostatic model assessment for insulin resistance (HOMA-IR) as a marker of CVD. Methods: Participants in this pilot analysis were on a stable atypical antipsychotic regimen for at least 6 months, with no diabetes diagnosis or use of antidiabetic medications. Participant samples were genotyped for MTHFR variants rs1801131 (MTHFR A1298C) and rs1801133 (MTHFR C677T). Serum metabolite concentrations were obtained with NMR. A least squares regression model was used to predict log(HOMA-IR) values based on the following independent variables: serum glutamate, glycine, betaine, serine, and threonine concentrations, and carrier status of the variant alleles for the selected genotypes. Results: A total of 67 participants...Continue Reading

References

Oct 21, 1991·Nucleic Acids Research·D K Lahiri, J I Nurnberger
Nov 3, 2001·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·K J LieversH J Blom
Jun 26, 2003·The Journal of Clinical Psychiatry·Scott W Woods
May 27, 2004·Diabetes Care·Tara M WallaceDavid R Matthews
Aug 16, 2005·Methods in Molecular Biology·Sharon MarshHoward L McLeod
Nov 13, 2009·Diabetes Care·Ralph A DeFronzo, Devjit Tripathy
Nov 10, 2009·Trends in Molecular Medicine·M O KrebsHelge Frieling
Jun 16, 2010·Schizophrenia Research·Ruud van WinkelMarc De Hert
Oct 13, 2011·Pharmacogenetics and Genomics·Caroline F ThornRuss B Altman
Oct 29, 2011·Journal of Cellular Physiology·Caroline H Johnson, Frank J Gonzalez
Sep 22, 2012·Biochimica Et Biophysica Acta·Shelly C Lu
Jul 19, 2013·JAMA Psychiatry·Casey CrumpJan Sundquist
Feb 6, 2014·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Francesco Scaglione, Giscardo Panzavolta
Apr 23, 2015·Circulation. Cardiovascular Genetics·Svati H Shah, Christopher B Newgard
Sep 1, 2015·Journal of the American College of Cardiology·Laurence S SperlingScott M Grundy
Sep 27, 2015·World Psychiatry : Official Journal of the World Psychiatric Association (WPA)·Davy VancampfortChristoph U Correll
May 6, 2016·Cold Spring Harbor Molecular Case Studies·Clary B Clish
Jun 7, 2016·World Psychiatry : Official Journal of the World Psychiatric Association (WPA)·Davy VancampfortBrendon Stubbs
Aug 21, 2016·Bipolar Disorders·Kyle J BurghardtVicki L Ellingrod
Sep 20, 2016·Cell Metabolism·Gregory S Ducker, Joshua D Rabinowitz
Jul 25, 2017·Modern Trends in Pharmacopsychiatry·Ebrahim Haroon, Andrew H Miller
Jun 19, 2019·Nutrients·Anaïs AlvesBéatrice Morio
Oct 31, 2019·Molecular Genetics & Genomic Medicine·Yanzi MengGuijun Qin

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