Genetic and molecular alterations across medulloblastoma subgroups

Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte
Patryk SkowronMichael D Taylor

Abstract

Medulloblastoma is the most common malignant brain tumour diagnosed in children. Over the last few decades, advances in radiation and chemotherapy have significantly improved the odds of survival. Nevertheless, one third of all patients still succumb to their disease, and many long-term survivors are afflicted with neurocognitive sequelae. Large-scale multi-institutional efforts have provided insight into the transcriptional and genetic landscape of medulloblastoma. Four distinct subgroups of medulloblastoma have been identified, defined by distinct transcriptomes, genetics, demographics and outcomes. Integrated genomic profiling of each of these subgroups has revealed distinct genetic alterations, driving pathways and in some instances cells of origin. In this review, we highlight, in a subgroup-specific manner, our current knowledge of the genetic and molecular alterations in medulloblastoma and underscore the possible avenues for future therapeutic intervention.

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Citations

Jul 5, 2016·Critical Reviews in Oncology/hematology·Maura MassiminoStefan Rutkowski
May 6, 2017·Annual Review of Genomics and Human Genetics·Borja L HolgadoMichael D Taylor
May 11, 2018·Journal of Korean Neurosurgical Society·Claudia Miranda Kuzan-FischerMichael D Taylor
Jul 28, 2019·Cytotechnology·Ricardo Bonfim-SilvaAparecida Maria Fontes
Jul 11, 2018·Cancers·Maider Varela-GuruceagaMarta M Alonso
Apr 17, 2018·Neurosurgery·Prayash PatelPaul Klimo
Nov 17, 2020·Frontiers in Oncology·Mario CapassoAchille Iolascon
Jan 13, 2021·International Journal of Molecular Sciences·Renata GruszkaMagdalena Zakrzewska

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