PMID: 1495987Aug 1, 1992

Genetic and molecular analysis of recessive alleles at the pink-eyed dilution (p) locus of the mouse

Proceedings of the National Academy of Sciences of the United States of America
M F LyonMurray H Brilliant

Abstract

Recessive mutant alleles at the pink-eyed dilution (p) locus on mouse chromosome 7 reduce pigmentation of both the coat and eyes. Here we describe the properties and complementation interactions of 10 p alleles, including 6 not previously reported. Several alleles that cause additional phenotypes affecting development, reproduction, and behavior were shown to be deletions by using DNA probes derived from the p region. An alignment of functional and marker-defined units is proposed, giving a linear complementation map that orders at least four functional loci. The characterization of a nested set of deletions around p will facilitate detailed molecular analyses of the genes and developmental functions associated with this part of the mouse genome.

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Related Concepts

Conditions, Recessive Genetic
Southern Blot Result
Partial Monosomy
Alleles
Mice, Mutant Strains
Crosses, Genetic
Mice, Inbred Strains
DNA, Double-Stranded

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