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Genetic and non-genetic instability in tumor progression: link between the fitness landscape and the epigenetic landscape of cancer cells

Cancer Metastasis Reviews

May 4, 2013

Sui Huang

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Abstract

Genetic instability is invoked in explaining the cell phenotype changes that take place during cancer progression. However, the coexistence of a vast diversity of distinct clones, most prominently visible in the form of non-clonal chromosomal aberrations, suggests that Darwinian selecti...read more

Mentioned in this Paper

Genomic Stability
Cancer Progression
Cell Differentiation Process
Primary Malignant Neoplasm
Study of Epigenetics
Clone
Tumor Cells, Malignant
Chromosome Aberrations
Mutant
Gene Regulatory Networks
2
144
Paper Details
References
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  • Citations31
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Genetic and non-genetic instability in tumor progression: link between the fitness landscape and the epigenetic landscape of cancer cells

Cancer Metastasis Reviews

May 4, 2013

Sui Huang

PMID: 23640024

DOI: 10.1007/s10555-013-9435-7

Abstract

Genetic instability is invoked in explaining the cell phenotype changes that take place during cancer progression. However, the coexistence of a vast diversity of distinct clones, most prominently visible in the form of non-clonal chromosomal aberrations, suggests that Darwinian selecti...read more

Mentioned in this Paper

Genomic Stability
Cancer Progression
Cell Differentiation Process
Primary Malignant Neoplasm
Study of Epigenetics
Clone
Tumor Cells, Malignant
Chromosome Aberrations
Mutant
Gene Regulatory Networks
2
144

Feeds With Similar Papers

Chromosomal Abnormalities

Chromosome abnormalities can be classified as either structural or numerical. Numerical abnormalities include duplications or deletion of a pair of chromosomes, such as Down Syndrome. Structural abnormalities include missing, extra or switched parts of a chromosome. Discover the latest research on chromosomal abnormalities here.

Gene Regulatory Networks (Keystone)

Gene regulatory networks are comprised of molecular regulators that interact with each other and other factors in a cell to regulate and modulate gene expression. Here is the latest research.

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Paper Details
References
  • References120
  • Citations31
12345...
  • References120
  • Citations31
1234

Download from

Publisher
PubMed
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