Genetic and phenotypic diversity among isolates of Streptococcus pyogenes from invasive infections

The Journal of Infectious Diseases
M S ChausseeJ J Ferretti

Abstract

To determine if recent cases of invasive group A streptococcal disease were caused by strains with a unique characteristic, 117 isolates Streptococcus pyogenes from patients with a variety of diseases, including necrotizing fasciitis and toxic shock syndrome, were analyzed. Significant genomic heterogeneity was observed among selected isolates, as determined using pulsed-field gel electrophoresis. The frequency of the bacteriophage-associated streptococcal erythrogenic toxin genes A and C (speA and speC) among the isolates was 44% (49/112) and 34% (38/112), respectively. Forty-three percent of speA-positive isolates produced streptococcal erythrogenic toxin (SPE) A in vitro. Seventy-six percent (85/112) of isolates produced SPE B in vitro, and in contrast to SPE A, little variation in the concentration of SPE B in broth culture supernatants was detected. The genetic and phenotypic heterogeneity observed among isolates from recent cases of severe infection does not support a clonal basis for the resurgence of invasive streptococcal infections.

Citations

Nov 30, 2000·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·F Baxter, J McChesney
Sep 19, 2003·Current Infectious Disease Reports·Dennis L. Stevens
May 24, 2000·Comprehensive Therapy·T M File, J S Tan
Oct 9, 2002·Molecular Microbiology·Carlos Hidalgo-GrassEmanuel Hanski
Feb 24, 2001·Cellular Microbiology·G MolinariG S Chhatwal
Mar 28, 2002·Proceedings of the National Academy of Sciences of the United States of America·James C SmootJames M Musser
Oct 18, 2000·Infection and Immunity·B LimbagoJ R Scott
Jan 13, 2004·Journal of Clinical Microbiology·Shinnosuke HashikawaMichio Ohta
Apr 25, 2000·Annual Review of Medicine·D L Stevens
Nov 16, 2010·Future Microbiology·Alexander V Dmitriev, Michael S Chaussee
May 4, 2013·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Po-Chuang WuChih-Chien Wang
Sep 18, 2008·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Chuan Chiang-Ni, Jiunn-Jong Wu
Jun 12, 1998·Pediatric Annals·S Ahmed, E M Ayoub
Apr 27, 2007·International Journal of Medical Microbiology : IJMM·David J McMillanGursharan S Chhatwal
Nov 20, 1998·The Journal of Infection·J AliskyN Troitsky
May 26, 2004·Acta Tropica·Jesse D Miller, Melody N Neely
Mar 1, 1997·Current Problems in Pediatrics·E M Ayoub, S Ahmed
Sep 17, 1998·Journal of the American Academy of Dermatology·S M Manders
Nov 14, 2001·Dermatologic Clinics·S M Manders
Sep 24, 2008·Journal of Medical Microbiology·Robert CommonsNigel Curtis
Apr 2, 2005·Clinics in Dermatology·Erika Gaines Levine, Steven M Manders
May 28, 2005·Expert Review of Anti-infective Therapy·Michael H YoungN Cary Engleberg
Aug 10, 2004·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Eulogio BesadaScott Schatz
Apr 15, 2006·Journal of Korean Medical Science·Eun Ha KohSunjoo Kim
Nov 5, 2008·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Eulogio Besada, Barry J Frauens
Sep 17, 2011·Nature Reviews. Microbiology·Jason N ColeMark J Walker
Feb 19, 2000·Scandinavian Journal of Infectious Diseases·A NordstrandS E Holm

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacteriophage: Phage Therapy

Phage therapy uses bacterial viruses (bacteriophages) to treat bacterial infections and is widely being recognized as an alternative to antibiotics. Here is the latest research.