PMID: 11311430Apr 20, 2001Paper

Genetic and serotypic characterization of Sin Nombre-like viruses in Canadian Peromyscus maniculatus mice

Virus Research
M A DrebotH Artsob

Abstract

In Canada, hantavirus infected deer mice (Peromyscus maniculatus) have been collected from British Columbia to Newfoundland. Partial sequencing of G1 and N protein encoding regions from Canadian Peromyscus maniculatus-borne hantaviruses demonstrated the existence of significant genotypic divergence among strains. Phylogenetic analysis showed that Sin Nombre (SN)-like viruses from eastern and western Canadian deer mice can be divided into at least two broad-based genogroups. Sequencing of mitochondrial DNA from infected deer mice originating from various eastern and western provinces showed that SN-like virus genogroups appeared to be associated with distinct haplotypes of mice. Sera from deer mice infected with eastern and western viral genotypes neutralized the Sin Nombre virus strain, Convict Creek 107, but not the New York 1 hantavirus. Despite the genetic heterogeneity of Canadian SN-like strains these hantaviruses do not appear to define unique hantavirus serotypes.

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Citations

May 25, 2005·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Jonas SchmidtRainer Ulrich
Jan 9, 2010·Vector Borne and Zoonotic Diseases·Mary L MilazzoCharles F Fulhorst
May 12, 2010·Vector Borne and Zoonotic Diseases·Adrian N BillingsCharles F Fulhorst
May 13, 2009·Southern Medical Journal·Donald C Vinh, John M Embil
Mar 22, 2002·Journal of Virology·Marlene C BohlmanStephen C St Jeor
Jun 8, 2007·Emerging Infectious Diseases·Charles F FulhorstThomas G Ksiazek
Jan 1, 2008·Journal of Infection and Public Health·Nevio Cimolai, Tomas Cimolai
Jun 1, 2009·Journal of Vector Ecology : Journal of the Society for Vector Ecology·Tyla S HolsombackBrandon E L Morris
Aug 25, 2015·Applied and Environmental Microbiology·N H OgdenT J Moriarty
May 2, 2018·EcoHealth·Matthew T MilhollandJames N Mills
Nov 22, 2020·Emerging Infectious Diseases·Bryce M WarnerDavid Safronetz

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