PMID: 9536823Apr 16, 1998Paper

Genetic anticipation in Behçet's syndrome

Annals of the Rheumatic Diseases
Izzet FreskoH Yazici

Abstract

To examine the presence of genetic anticipation in families with Behçet's syndrome (BS). A total of 18 families with 40 affected members in two successive generations were evaluated by interviewing them for their ages at the onset of the first symptom of BS and for their ages at the time they fulfilled the diagnostic criteria. It was noted that the age of onset of the first symptom was lower in the second generation in 14 families (p = 0.01) with a mean (SD) age of 20.57 (7.47) years in the children compared with 33.29 (9.92) years in the parents (t = 7.79, p < 0.0001), whereas the diagnostic criteria were fulfilled at an earlier age in the children in 15 families (p = 0.01) with a mean age of 21.2 (6.74) years in the children compared with 36.4 (9.55) years in the parents (t = 7.41, p < 0.0001). Genetic anticipation was present in 15 of 18 (84%) of the families with BS in the form of earlier disease onset in the children compared with their parents.

Citations

Sep 5, 2008·Rheumatology International·Won-Cheoul JangSeong-Kyu Kim
Jul 4, 2009·Rheumatology International·Sema Yilmaz, Kadriye Akar Cimen
Feb 19, 2013·Rheumatology International·Jung-Yoon ChoeSeong-Kyu Kim
Jun 8, 2012·Clinical Reviews in Allergy & Immunology·H YaziciE Seyahi
Jul 12, 2008·The Journal of Laryngology and Otology·C J WebbA C Swift
Mar 6, 2007·Nature Clinical Practice. Rheumatology·Hasan YaziciSebahattin Yurdakul
Sep 30, 1999·Current Opinion in Rheumatology·S Ozen
Feb 26, 2000·The New England Journal of Medicine·G E Ehrlich
Aug 21, 2003·The British Journal of Ophthalmology·D H VerityM R Stanford
Aug 28, 2012·American Journal of Respiratory and Critical Care Medicine·Emma K LarkinJames E Loyd
Dec 27, 2012·Annals of the Rheumatic Diseases·Qingyun ZhouPeizeng Yang
Nov 15, 2006·Rheumatology International·Mehmet SoyArmagan Tugrul
Oct 12, 2012·Rheumatology International·Mehmet Melikoglu, Meltem Alkan Melikoglu
Oct 21, 2011·Pathology Research International·Tamer İrfan Kaya
Nov 30, 2007·Journal of the American Academy of Dermatology·Yelda KarincaogluErkan Alpsoy
Jul 12, 2017·Journal of Immunotoxicology·Arash SalmaninejadMasoud Zal
May 29, 2004·Current Opinion in Neurology·Aksel SivaSabahattin Saip
Sep 5, 2003·American Journal of Medical Genetics. Part a·N MolinariI Touitou
Jul 21, 2009·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·G MumcuH Direskeneli
Jun 4, 2005·Arthritis and Rheumatism·Jumana KarasnehJane Worthington
Jul 23, 2008·International Ophthalmology Clinics·Nobuyoshi Kitaichi, Shigeaki Ohno
May 29, 2004·Clinical Rheumatology·Alzírton de Lira FreireSandra Regina Muchinechi Fernandes
Jan 25, 2008·Seminars in Ophthalmology·K Durrani, G N Papaliodis
Jan 23, 1999·Current Opinion in Rheumatology·H YaziciV Hamuryudan
Nov 12, 2002·International Reviews of Immunology·Giuseppina Pennesi, Rachel R Caspi
Jan 10, 2001·Current Opinion in Rheumatology·H YaziciV Hamuryudan
Mar 24, 2018·Brain and Behavior·Vanesa PytelJorge Matías-Guiu
Sep 22, 2020·World Journal of Gastrointestinal Pharmacology and Therapeutics·Brindusa TrutaSteven R Brant
Jul 13, 2001·Ocular Immunology and Inflammation·S OnalA Gul
Jul 10, 2019·Dermatology : International Journal for Clinical and Investigative Dermatology·Zübeyde Ceylan KalınEmel Bülbül Başkan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.