Genetic approach to variability of memory systems: analysis of place vs. response learning and fos-related expression in hippocampal and striatal areas of C57BL/6 and DBA/2 mice

Hippocampus
E PassinoM Ammassari-Teule

Abstract

C57 and DBA mice were trained in a crossed maze to assess possible strain differences in place or response learning as a function of training duration (8 or 17 days) and extramaze cueing conditions. The first condition consisted of a diffuse visually cued environment (rich cueing). The second was the same plus an explicit visual cue marking the direction of the baited arm (rich cueing plus cue). The third was a featureless environment (poor cueing). During training, mice were released from the south arm and rewarded in the east arm. Probe trials on which mice were released from the north arm and allowed to choose either the east (place learning) or the west (response learning) arm were given either on the ninth (PT1) or the eighteenth (PT2) days. Strain x context differences in the activation of the dorsal hippocampus and the dorsolateral striatum were examined by analyzing Fos expression following each probe trial. Results first showed that C57 were essentially place-learners, whereas no learning modality was predominant in DBA, except on the PT2 run with the explicit cue available. Examination of Fos expression in C57 trained under "rich cueing" and "rich cueing plus cue" conditions revealed a strong and parallel increase of ...Continue Reading

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Citations

Sep 28, 2002·Neuroreport·Martine Ammassari-TeuleLeonardo Restivo
Dec 6, 2003·Learning & Memory·Michelle M NicolleJennifer L Bizon
Nov 9, 2011·PloS One·Rick JansenKlaus Linkenkaer-Hansen
Mar 6, 2010·Frontiers in Behavioral Neuroscience·Fanny Botreau, Pascale Gisquet-Verrier
Sep 17, 2014·Proceedings of the National Academy of Sciences of the United States of America·Christiane SchreiweisAnn M Graybiel
Feb 13, 2003·The European Journal of Neuroscience·Khalid TouzaniRobert Jaffard
Jul 26, 2014·Animal Cognition·Shaina P A CahillDarlene M Skinner
Sep 13, 2017·PLoS Biology·Omar MamadMarian Tsanov
Dec 18, 2008·Neuroscience and Behavioral Physiology·A P Bel'nikI I Poletaeva
Nov 28, 2006·Neurobiology of Aging·Amy R DeipolyiLennart Mucke
Mar 26, 2011·Learning & Memory·Elvira De LeonibusAndrea Mele

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