Genetic approaches to the study of anxiety

Annual Review of Neuroscience
Joshua A Gordon, René Hen

Abstract

Anxiety and its disorders have long been known to be familial. Recently, genetic approaches have been used to clarify the role of heredity in the development of anxiety and to probe its neurobiological underpinnings. Twin studies have shown that a significant proportion of the liability to develop any given anxiety disorder is due to genetic factors. Ongoing efforts to map anxiety-related loci in both animals and humans are underway with limited success to date. Animal models have played a large role in furthering our understanding of the genetic basis of anxiety, demonstrating that the genetic factors underlying anxiety are complex and varied. Recent advances in molecular genetic techniques have allowed increasing specificity in the manipulation of gene expression within the central nervous system of the mouse. With this increasing specificity has come the ability to ask and answer precise questions about the mechanisms of anxiety and its treatment.

References

Oct 1, 1975·Behavior Genetics·P L Broadhurst
Jan 1, 1987·Psychopharmacology·R G Lister
Jan 1, 1988·Psychopharmacology·S R BodnoffM J Meaney
Aug 1, 1987·The American Journal of Psychiatry·R NoyesC M McChesney
Jul 1, 1995·Archives of General Psychiatry·A J FyerD F Klein
Dec 5, 1994·Neuroscience Letters·F ChaouloffP Mormède
Sep 1, 1994·Pharmacology, Biochemistry, and Behavior·A P CruzF G Graeff
Jan 1, 1993·Psychopharmacology·R Trullas, P Skolnick
Mar 1, 1994·Pharmacology, Biochemistry, and Behavior·C L Melchior, R F Ritzmann
Apr 1, 1994·Biological Psychiatry·C GrillonM Davis
Jan 1, 1993·Journal of Psychiatric Research·M M Weissman
May 1, 1993·American Journal of Medical Genetics·M J LyonsW G Henderson
Feb 15, 1993·Biological Psychiatry·D QuartermainA Shemer
Sep 15, 1995·Biological Psychiatry·C A MorganD S Charney
Oct 1, 1995·Pharmacology, Biochemistry, and Behavior·R J Rodgers, N J Johnson
May 1, 1996·Pharmacology, Biochemistry, and Behavior·S E File
May 1, 1996·Pharmacology, Biochemistry, and Behavior·M V PletnikovV V Sherstnev
May 1, 1996·Pharmacology, Biochemistry, and Behavior·A RexH Fink
Oct 15, 1996·Proceedings of the National Academy of Sciences of the United States of America·Z NusserP Somogyi
Jan 17, 1997·The Journal of Biological Chemistry·M YedovitzkyR Nesher
Apr 1, 1997·Behavioural Brain Research·A RamosF Chaouloff
Mar 28, 1997·Brain Research·Y ClémentG Chapouthier
Jan 7, 1998·Neuroscience and Biobehavioral Reviews·R J Rodgers, A Dalvi
Jun 6, 1998·Proceedings of the National Academy of Sciences of the United States of America·C CaldjiM J Meaney

❮ Previous
Next ❯

Citations

Apr 26, 2011·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Geison S IzídioAndré Ramos
Apr 3, 2009·Journal of Neural Transmission·Christa Hohoff
Apr 17, 2007·Neuropsychology Review·Martin P Paulus, Murray B Stein
Oct 28, 2005·Proceedings of the National Academy of Sciences of the United States of America·Michael M ScottEvan S Deneris
Aug 19, 2007·Journal of Asian Natural Products Research·Song LiMin-Wei Wang
Nov 17, 2010·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Kees van Oers, Jakob C Mueller
May 10, 2006·Genes, Brain, and Behavior·C StoppelO Stork
Apr 30, 2009·Annual Review of Neuroscience·Peter Dayan, Quentin J M Huys
Jun 26, 2004·Annual Review of Neuroscience·Takao K Hensch
May 11, 2013·Biology of Mood & Anxiety Disorders·Ewa Sokolowska, Iiris Hovatta
Apr 4, 2008·Neurochemical Research·Long-Jun WuMin Zhuo
Feb 18, 2016·Trends in Neurosciences·Min Zhuo
Jun 2, 2012·Expert Opinion on Drug Discovery·Adam StewartAllan V Kalueff
Feb 23, 2008·Annals of Medicine·Iiris Hovatta, Carrolee Barlow
Dec 7, 2011·The Journal of Pain : Official Journal of the American Pain Society·William MaixnerGary D Slade
May 5, 2009·Lancet·Paul Ramchandani, Lamprini Psychogiou
Jul 1, 2011·International Journal of Evolutionary Biology·Noémie ChervetDik Heg
Jun 21, 2008·Hippocampus·Mark I Ransome, Ann M Turnley
Mar 10, 2015·Journal of Research on Adolescence : the Official Journal of the Society for Research on Adolescence·Ben T ReebKatherine J Conger
Jun 27, 2006·Biological Psychiatry·Alex Dranovsky, René Hen
May 25, 2006·Journal of the American Academy of Child and Adolescent Psychiatry·Paul G RamchandaniUNKNOWN ALSPAC STUDY TEAM
Oct 15, 2013·Progress in Neuro-psychopharmacology & Biological Psychiatry·Li-Tao YiDi Wu
May 16, 2007·Neural Plasticity·Yan ClémentGeorges Chapouthier
Jan 10, 2012·Biological Psychology·Tom BeckersMerel Kindt
Sep 21, 2010·Molecular and Cellular Neurosciences·Yasunari YamanakaToshio Heike
Mar 10, 2015·ELife·Prabhat S KunwarDavid J Anderson
May 20, 2009·Cell·Antonio RiccioDavid E Clapham
Jan 26, 2013·Current Biology : CB·Ralph Adolphs

❮ Previous
Next ❯

Methods Mentioned

BETA
transgenics
sedation
Knockout

Related Concepts

Related Feeds

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Barrel cortex

Here is the latest research on barrel cortex, a region of somatosensory and motor corticies in the brain, which are used by animals that rely on whiskers for world exploration.