PMID: 12775337May 31, 2003Paper

Genetic approaches to visual transduction in Drosophila melanogaster

Receptors & Channels
William L Pak, Hung-Tat Leung

Abstract

Because almost everything we know about Drosophila phototransduction has come from studies based on genetic approaches, this review begins with a discussion of genetic approaches. We then present a brief overview of Drosophila phototransduction (section on Drosophila phototransduction: an overview) followed by a more detailed treatment of individual components of the transduction machinery (section on Components of the phototransduction machinery). Discussion of transduction mechanisms is presented under three headings: Mechanism(s) of channel excitation, Organization of the transduction proteins, and Regulatory mechanisms in phototransduction. Perhaps the most important unanswered question in this field is the mechanism(s) of activation and regulation of transduction channels. This question is explored in the section entitled Mechanism(s) of channel excitation. Identification of at least two of the proteins discussed was totally unexpected: the rhodopsin chaperone protein, ninaA, and the signal complex scaffold protein, INAD. They are discussed in the sections titled Requirement for a chaperone protein for Rh1 opsin, and: Formation of signaling complexes, respectively. One of the important developments in this field has been t...Continue Reading

Citations

Sep 3, 2003·Progress in Neurobiology·Mimi Halpern, Alino Martínez-Marcos
Feb 16, 2006·Science's STKE : Signal Transduction Knowledge Environment·Richard G Vogt
Aug 3, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Inga KristaponyteBih-Hwa Shieh
Feb 8, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ning WangBih-Hwa Shieh
Apr 4, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·A Ashleigh LongKendal Broadie
Feb 11, 2004·Proceedings of the National Academy of Sciences of the United States of America·Usha AcharyaJairaj K Acharya
Jun 12, 2010·Journal of Neurogenetics·William L Pak
Feb 9, 2012·Science China. Life Sciences·Yao TianJunhai Han
Feb 6, 2004·Journal of Biochemistry and Molecular Biology·Chunming Ding, Charles R Cantor
Feb 6, 2004·Journal of Biochemistry and Molecular Biology·Changsoo Kim
Feb 6, 2004·Journal of Biochemistry and Molecular Biology·Elahe ElahiMostafa Ronaghi
Jul 12, 2005·Current Biology : CB·Yuchun GuRoger C Hardie
Sep 19, 2006·Vision Research·Michael NatochinNikolai O Artemyev
Feb 9, 2006·The Journal of Biological Chemistry·Syed Tariq AhmadJoseph E O'Tousa
Dec 14, 2004·American Journal of Physiology. Cell Physiology·Whaseon Lee-KwonEdward J Weinman

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.