Genetic architecture of fatty acid composition in the longissimus dorsi muscle revealed by genome-wide association studies on diverse pig populations

Genetics, Selection, Evolution : GSE
Wanchang ZhangBin Yang

Abstract

Fatty acid composition in muscle is an important factor that affects the nutritive value and taste of pork. To investigate the genetic architecture of fatty acid composition of pork, we measured fatty acid contents in longissimus dorsi muscle of 1244 pigs from three divergent populations and conducted genome-wide association studies (GWAS) for fatty acid contents. We detected 26 genome-wide significant quantitative trait loci (QTL) on eight chromosomes (SSC for Sus scrofa) for eight fatty acids. These loci not only replicated previously reported QTL for C18:0 on SSC14 and C20:0 on SSC16, but also included several novel QTL such as those for C20:1 on SSC7, C14:0 on SSC9, and C14:0, C16:0 and C16:1 on SSC12. Furthermore, we performed a meta-analysis of GWAS on five populations, including the three populations that were investigated in this study and two additional populations that we had previously examined. This enhanced the strength of the associations detected between fatty acid composition and several marker loci, especially for those for C18:0 on SSC14 and C20:0 on SSC16. The genes ELOVL5, ELOVL6, ELOVL7, FASN, SCD and THRSP, which have functions that are directly relevant to fatty acid metabolism, are proximal to the top as...Continue Reading

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Citations

Apr 13, 2017·Animal Science Journal = Nihon Chikusan Gakkaihō·Shuji SatoKeiichi Suzuki
Sep 25, 2017·Journal of Animal Breeding and Genetics = Zeitschrift Für Tierzüchtung Und Züchtungsbiologie·J ZhangB Yang
Nov 15, 2020·Animals : an Open Access Journal From MDPI·Houda LaghouaoutaAgustín Blasco

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Methods Mentioned

BETA
dissection
chips
chip

Software Mentioned

METAL
gplots
GEMMA
R package GenABEL
Plink
R

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