Jun 24, 2015

Genetic architecture of natural variation in Drosophila melanogaster aggressive behavior

Proceedings of the National Academy of Sciences of the United States of America
John ShorterTrudy F C Mackay

Abstract

Aggression is an evolutionarily conserved complex behavior essential for survival and the organization of social hierarchies. With the exception of genetic variants associated with bioamine signaling, which have been implicated in aggression in many species, the genetic basis of natural variation in aggression is largely unknown. Drosophila melanogaster is a favorable model system for exploring the genetic basis of natural variation in aggression. Here, we performed genome-wide association analyses using the inbred, sequenced lines of the Drosophila melanogaster Genetic Reference Panel (DGRP) and replicate advanced intercross populations derived from the most and least aggressive DGRP lines. We identified genes that have been previously implicated in aggressive behavior as well as many novel loci, including gustatory receptor 63a (Gr63a), which encodes a subunit of the receptor for CO2, and genes associated with development and function of the nervous system. Although genes from the two association analyses were largely nonoverlapping, they mapped onto a genetic interaction network inferred from an analysis of pairwise epistasis in the DGRP. We used mutations and RNAi knock-down alleles to functionally validate 79% of the candi...Continue Reading

Mentioned in this Paper

Genes, Insect
Genome-Wide Association Study
CFC1 gene
Hierarchy
Gene Knockdown Techniques
Gr63a
Genes
Cosuppression
Drosophila melanogaster Proteins
Entire Nervous System

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