Genetic architecture of testis and seminal vesicle weights in mice.

Genetics
I Le RoyP Roubertoux

Abstract

Comparisons across 13 inbred strains of laboratory mice for reproductive organ (paired seminal vesicles and paired testes) weights indicated a very marked contrast between the C57BL/6By and NZB/BINJ mice. Subsequently these strains were selected to perform a quantitative genetic analysis and full genome scan for seminal vesicle and testis weights. An F(2) population was generated. The quantitative genetic analyses indicated that each was linked to several genes. Sixty-six short sequences for length polymorphism were used as markers in the wide genome scan strategy. For weight of paired testes, heritability was 82.3% of the total variance and five QTL contributed to 72.8% of the total variance. Three reached a highly significant threshold (>4.5) and were mapped on chromosome X (LOD score 9.11), chromosome 4 (LOD score 5.96), chromosome 10 (LOD score 5.81); two QTL were suggested: chromosome 13 (LOD score 3.10) and chromosome 18 (LOD score 2.80). Heritability for weight of seminal vesicles was 50.7%. One QTL was mapped on chromosome 4 (LOD score 9.21) and contributed to 24.2% of the total variance. The distance of this QTL to the centromere encompassed the distance of the QTL linked with testicular weight on chromosome 4, suggest...Continue Reading

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Citations

Jan 1, 2009·Animal : an International Journal of Animal Bioscience·P LaissueD Vaiman
May 5, 2012·Genetics·Michael A WhiteBret A Payseur
Mar 29, 2003·Genetics·Pierre L RoubertouxDanièle Migliore-Samour
Nov 5, 2008·International Journal of Obesity : Journal of the International Association for the Study of Obesity·G A Ankra-BaduN Yi
Jun 16, 2010·Reproduction in Domestic Animals = Zuchthygiene·J OgorevcT Kunej

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