PMID: 7026414Jan 1, 1981Paper

Genetic aspects of H-Y antigen

Human Genetics
U Wolf

Abstract

While it remains to be clarified what detection of H-Y antigen by current methods means, the existence of a factor governing testicular differentiation of the indifferent gonadal anlage seems to be well established. There are various kinds of evidence that H-Y antigen as a biologically meaningful factor has a complex genetical basis. There is the contribution of the Y chromosome which, independent of the number of other chromosomes, especially of X chromosomes, leads to a male phenotype. The X chromosome must be involved also because structural aberrations of its distal short arm influence the expression of the H-Y structural gene. Due to examples of autosomal inheritance of various forms of sex reversal, an autosomal gene is assumed to be involved as well. Arguments are presented favoring the assumption that the structural H-Y gene is autosomal, while genes on the X and Y chromosomes have a controlling function. This genetic control mechanism for H-Y antigen seems to have evolved secondary to placentation in mammals. In non-mammalian vertebrates, H-Y antigen is controlled by other factors, e.g. steroid hormones. While the functional role of H-Y antigen in directing differentiation of the heterogametic gonad appears to have bee...Continue Reading

Citations

Mar 19, 2011·Skinmed·Naili MaW Clark Lambert
Jun 1, 1984·Journal of Endocrinological Investigation·C BoucekkineM Bachammar
Jan 1, 1982·Human Genetics·M FraccaroE M Ritzén
Jan 1, 1984·Molecular & General Genetics : MGG·H S Chandra
Apr 1, 1989·American Journal of Reproductive Immunology : AJRI·B F Heslop
Mar 1, 1983·American Journal of Reproductive Immunology : AJRI·G C KooL L Cederqvist
Apr 1, 1983·Journal of Immunogenetics·P E Polani, M Adinolfi
Jan 12, 1984·Nature·G GuellaenJ Weissenbach
Jan 7, 1982·Nature·P N Goodfellow, P W Andrews
Dec 1, 1989·Journal of Dairy Science·M P Bradley
May 1, 1986·Equine Veterinary Journal·M M Power
Jan 1, 1983·Clinical Genetics·U MüllerO Zuffardi

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