Genetic aspects of hypertension and metabolic disease in the obstructive sleep apnoea-hypopnoea syndrome

Sleep Medicine Reviews
Renata L RihaManagement Committee, COST B26 Action on Sleep Apnoea Syndrome

Abstract

Though it has long been recognised that there is a hereditary component to the obstructive sleep apnoea/hypopnoea syndrome (OSAHS), identifying its genetic basis remains elusive. Hypertension and metabolic syndrome, like OSAHS, are polygenic disorders, physiologically complex and the product of highly organised, hierarchical systems within the body. Elucidating their genetic basis is difficult when they are considered in isolation but even more difficult if their interrelationships with each other are brought into play. Not least of the problems is the lack of adequate and consistent phenotyping, which has hampered genetic dissection of these diseases; in addition, sleep-disordered breathing has not been factored into most studies dealing with essential hypertension or metabolic syndrome. Genome-wide scans have yielded inconsistent results in all three disorders under discussion and candidate gene studies of possible regulatory molecules require more rigorous replication. One approach would be to use 'intermediate' phenotypes and dense mapping of candidate genes for identifying genotype-phenotype correlations. This review focuses on genetic factors, which may be responsible for the expression of cardiovascular disease and metab...Continue Reading

References

Jul 5, 1990·The New England Journal of Medicine·J A PanzaS E Epstein
Feb 1, 1984·Chest·K R RajagopalC J Tellis
Oct 1, 1995·The Journal of Clinical Investigation·V K SomersF M Abboud
Mar 1, 1994·American Journal of Respiratory and Critical Care Medicine·C L MarcusS L Ward
Mar 1, 1996·Stroke; a Journal of Cerebral Circulation·M E DykenM B Zimmerman
Jan 1, 1997·American Journal of Respiratory and Critical Care Medicine·S RedlineK Spry
Feb 23, 1999·Clinical and Experimental Pharmacology & Physiology·D V Faller
Jan 5, 2000·American Journal of Respiratory and Critical Care Medicine·H W DuchnaT F Blaschke
Mar 8, 2000·The European Respiratory Journal·F GrimpenS Andreas
Mar 21, 2000·Respiration Physiology·B G Phillips, V K Somers
May 11, 2000·The New England Journal of Medicine·P E PeppardJ Skatrud
Aug 10, 2000·The European Respiratory Journal·S Saarelainen, J Hasan
Oct 4, 2000·Hypertension Research : Official Journal of the Japanese Society of Hypertension·J ZhangL Liu
Dec 9, 2000·American Journal of Respiratory and Critical Care Medicine·M S IpW K Lam
Dec 20, 2000·Proceedings of the National Academy of Sciences of the United States of America·A H KissebahA G Comuzzie
Feb 17, 2001·American Journal of Respiratory and Critical Care Medicine·J F FaccendaN J Douglas
Jun 13, 2001·JAMA : the Journal of the American Medical Association·H KadotaniE Mignot
Dec 12, 2001·British Journal of Clinical Pharmacology·A K Daly, C P Day
Jan 10, 2002·American Journal of Respiratory and Critical Care Medicine·Richard SchulzFriedrich Grimminger
Jan 16, 2002·JAMA : the Journal of the American Medical Association·Earl S FordWilliam H Dietz
May 30, 2002·Circulation·Abu S M ShamsuzzamanVirend K Somers
Oct 23, 2002·Journal of Applied Physiology·Eijiro OhgaYasuyoshi Ouchi
Dec 31, 2002·American Journal of Human Genetics·Lyle J PalmerSusan Redline
Jan 18, 2003·Sleep Medicine Reviews·Susan Redline, Peter V. Tishler
Jul 16, 2003·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·F E von EybenR von Eyben
Oct 9, 2003·JAMA : the Journal of the American Medical Association·Abu S M ShamsuzzamanVirend K Somers
Oct 28, 2003·Diabetes·Weihong TangUNKNOWN National Heart, Lung, and Blood Institute Family Heart Study
Dec 13, 2003·The Journal of Clinical Endocrinology and Metabolism·Ruth J F LoosUNKNOWN HERITAGE Family Study
Feb 21, 2004·BMC Genetics·Matthew B McQueenSusan L Santangelo
Feb 21, 2004·BMC Genetics·Catherine M SteinSudha K Iyengar
Mar 30, 2004·Diabetes·Carl D LangefeldUNKNOWN Insulin Resistance Atherosclerosis Study Family Study
Apr 9, 2004·American Journal of Respiratory and Critical Care Medicine·Lyle J PalmerSusan Redline
Jun 3, 2004·Circulation·James T Willerson, Paul M Ridker
Jul 6, 2004·The American Journal of Medicine·Antonia BarcelóAlvar G N Agustí

❮ Previous
Next ❯

Citations

May 19, 2010·Expert Review of Respiratory Medicine·Jamie C M Lam, Mary S M Ip
Nov 19, 2009·Advances in Medical Sciences·J WasilewskaJ Semeniuk
Mar 3, 2009·Progress in Cardiovascular Diseases·Allan I Pack, Thorarinn Gislason
Mar 17, 2009·Sleep Medicine Reviews·Tero AittokallioOlli Polo
Jan 19, 2008·Sleep Medicine Reviews·Ronald R GrunsteinPeter Y Liu
Apr 15, 2010·Therapeutic Advances in Respiratory Disease·Renata L Riha
May 9, 2014·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Gianfranco ParatiCarolina Lombardi
Jul 9, 2009·FEMS Microbiology Letters·Steffen Kolb
Jun 28, 2018·Obesity Surgery·Eric DeflandreBernard Bertrand

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

ApoE Phenotypes

Apolipoprotein E (APOE) is a protein involved in fat metabolism and associated with the pathogenesis of Alzheimer's disease and cardiovascular disease. Here is the latest research on APOE phenotypes.

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

Cell Adhesion Molecules in AS

Cell adhesion molecules expressed on the vascular endothelium and circulating leukocytes in response to inflammatory stimuli are implicated in atherosclerosis. Here is the latest research.

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Cancer Epigenetics & Metabolism (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. This feed focuses on the relationship between cell metabolism, epigenetics and tumor differentiation.

Related Papers

American Journal of Respiratory and Critical Care Medicine
Terry YoungDaniel J Gottlieb
American Journal of Respiratory and Critical Care Medicine
Michael ArztT Douglas Bradley
Proceedings of the American Thoracic Society
Naresh M Punjabi
Sleep Medicine Reviews
A N VgontzasGeorge P Chrousos
© 2021 Meta ULC. All rights reserved