Genetic aspects of susceptibility to air pollution

The European Respiratory Journal. Supplement
S R Kleeberger

Abstract

Inter-individual variation in human responses to air pollutants suggests that some subpopulations are at increased risk, and it is increasingly clear that genetic background is an important susceptibility factor. Genetically standardised animal models provide useful investigative tools. Linkage analyses using inbred mice identified chromosomal segments (quantitative trait loci (QTL)), with genes controlling susceptibility to the lung inflammatory (chromosome 17), injury (chromosome 11), and hyperpermeability (chromosome 4) responses to ozone (O3) exposure. An immune dysfunction response induced by exposure to sulphate-associated particles is linked to the identical chromosome 17 and 11 QTLs described for O3 susceptibility, thus similar genetic mechanisms may be controlling pulmonary responses to these pollutants. Candidate genes within the QTLs on chromosomes 4 and 17 include the toll-like receptor 4 and the pro-inflammatory cytokine, tumour necrosis factor-alpha, respectively. Functional analyses strongly support a role for these candidate genes in determining susceptibility to O3 and particulates. Because striking linkage homology exists between the human and mouse genomes, candidate susceptibility genes identified in the mou...Continue Reading

Citations

Mar 12, 2008·Journal of Occupational and Environmental Medicine·Mehrdad ArjomandiJohn R Balmes
Mar 13, 2012·Respirology : Official Journal of the Asian Pacific Society of Respirology·John W HollowayIan A Yang
Dec 7, 2010·American Journal of Physiology. Lung Cellular and Molecular Physiology·Stephan A CareyJack R Harkema
Apr 30, 2010·Proceedings of the American Thoracic Society·Isabelle RomieuStephanie J London
Sep 15, 2009·Environmental Health Perspectives·Petter LjungmanAnnette Peters
Dec 30, 2008·Human Genetics·Christopher M Somers, David N Cooper
Apr 21, 2010·Revue des maladies respiratoires·Y-M AllainG Huchon
Mar 31, 2007·Seminars in Radiation Oncology·Elizabeth L Travis
Apr 6, 2007·Pharmacology & Therapeutics·Radhika Kajekar
Jul 5, 2012·Annals of the New York Academy of Sciences·Concetta Gardi, Giuseppe Valacchi
Jan 11, 2005·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Klaus KayserEkkehard Vollmer
Nov 10, 2011·Inhalation Toxicology·Stephanie A ShoreMing Zhu
Sep 7, 2004·Current Opinion in Allergy and Clinical Immunology·Gillian S Backus-HazzardSteven R Kleeberger
Jun 9, 2015·Air Quality, Atmosphere, & Health·H Gawrońska, B Bakera
Jan 28, 2006·Journal of Applied Physiology·Jeffrey M Dodd-oDavid B Pearse
Jan 22, 2020·Journal of Applied Toxicology : JAT·Natália BruckerSolange Cristina Garcia
Sep 28, 2015·Respiratory Research·Kelsa GabehartAzzeddine Dakhama
Jan 30, 2004·Current Opinion in Pulmonary Medicine·Gary W K Wong, Chris K W Lai

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie
S R Kleeberger
American Journal of Respiratory and Critical Care Medicine
Joel Kaufman
© 2022 Meta ULC. All rights reserved