Genetic association and gene-smoking interaction study of carotid intima-media thickness at five GWAS-indicated genes: the Bogalusa Heart Study

Gene
Changwei LiHao Mei

Abstract

To examine the associations of five GWAS-identified genes with carotid intima-media thickness (IMT) in a biracial sample from the Bogalusa Heart Study, and evaluate their participation in gene-smoking interactions. Far wall IMTs of common carotid arteries were measured using high-resolution B-mode ultrasound. Both the gene-smoking interactions and single-marker associations were evaluated by linear models of carotid IMT levels, while the gene-based analyses were assessed through the truncated product method. A Bonferroni multiple testing correction was applied. Marker rs7840785 (PINX1) was significantly associated with right carotid IMT (p=0.0003) using all participants; mean levels for the CC, TC, and TT genotypes were 0.74 (0.73 to 0.75), 0.76 (0.75 to 0.78), and 0.78 (0.75, 0.81), respectively. Similar trends were observed in blacks (p=0.0031) and whites (p=0.0118). Marker rs7844465 (ZHX2) was significantly associated with left carotid IMT in whites (p=0.0005); mean IMT levels for the GG, TG, and TT genotypes were 0.73 (0.71 to 0.74), 0.75 (0.74 to 0.77) and 0.78 (0.75 to 0.81), respectively. Marker rs6841473 (EDNRA) modified the association between smoking and left carotid IMT in blacks (p=2.79×10(-5)). In addition, gene-ba...Continue Reading

Associated Clinical Trials

May 26, 2000·Lydia A. Bazzano

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Citations

Nov 2, 2015·Atherosclerosis·Daiane HemerichFolkert W Asselbergs
Jul 7, 2018·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Bianka ForgoAdam Domonkos Tarnoki
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Jan 27, 2018·Oncotarget·Qing-Hui ZhangShang-Ling Pan
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Jul 20, 2019·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Erica L ClinkenbeardBrett T Spear

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