Genetic association between Notch4 polymorphisms and Japanese schizophrenics

Psychiatric Genetics
Nobuto ShibataHeii Arai

Abstract

The objective of this study was to investigate whether three single nucleotide polymorphisms of the Notch4 gene are associated with the onset of schizophrenia. To confirm the linkage disequilibrium among these three single nucleotide polymorphisms of the gene, the three single nucleotide polymorphisms were genotyped by a polymerase chain reaction-restriction-fragment length polymorphism method for all samples. The genotypic frequencies of each single nucleotide polymorphism in the schizophrenic were compared with respective controls using a chi method. To check linkage disequilibrium, the haplotype frequency program was utilized. No statistical association between the two single nucleotide polymorphisms of the Notch4 gene and schizophrenia was observed in our Japanese samples. Although one nonsynonymous single nucleotide polymorphism did show a weakly significant P-value, its allelic frequencies are not positive. Two of the single nucleotide polymorphisms showed strong linkage disequilibrium in our Japanese samples. The single nucleotide polymorphism between the other two single nucleotide polymorphisms showed a weaker linkage disequilibrium with the others. Our study suggests that the three single nucleotide polymorphisms are ...Continue Reading

References

Aug 10, 2000·Nature Genetics·J Wei, G P Hemmings
Mar 11, 2003·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·A D SkolM T Tsuang
Jun 5, 2003·Psychiatric Genetics·Sami AnttilaEsa Leinonen
Jan 21, 2004·Biological Psychiatry·Xingguang LuoJoel Gelernter
Mar 11, 2004·Psychiatry and Clinical Neurosciences·Naoshi KanekoToshiyuki Someya
Apr 20, 2004·Psychiatric Genetics·Xuan ZhangGwynneth P Hemmings

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