Genetic association of apolipoprotein E with age-related macular degeneration

American Journal of Human Genetics
C C KlaverP T de Jong

Abstract

Age-related macular degeneration (AMD) is the most common geriatric eye disorder leading to blindness and is characterized by degeneration of the neuroepithelium in the macular area of the eye. Apolipoprotein E (apoE), the major apolipoprotein of the CNS and an important regulator of cholesterol and lipid transport, appears to be associated with neurodegeneration. The apoE gene (APOE) polymorphism is a strong risk factor for various neurodegenerative diseases, and the apoE protein has been demonstrated in disease-associated lesions of these disorders. Hypothesizing that variants of APOE act as a potential risk factor for AMD, we performed a genetic-association study among 88 AMD cases and 901 controls derived from the population-based Rotterdam Study in the Netherlands. The APOE polymorphism showed a significant association with the risk for AMD; the APOE epsilon4 allele was associated with a decreased risk (odds ratio 0.43 [95% confidence interval 0.21-0. 88]), and the epsilon2 allele was associated with a slightly increased risk of AMD (odds ratio 1.5 [95% confidence interval 0.8-2. 82]). To investigate whether apoE is directly involved in the pathogenesis of AMD, we studied apoE immunoreactivity in 15 AMD and 10 control macu...Continue Reading

References

May 1, 1976·The British Journal of Ophthalmology·S H Sarks
Jul 1, 1992·Genomics·K W SmallM A Pericak-Vance
May 11, 1991·Lancet·P R WenhamG Blandell
Jul 1, 1991·European Journal of Epidemiology·A HofmanF A van den Ouweland
Nov 14, 1991·The New England Journal of Medicine·A SommerS Ezrine
Feb 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·M J IgnatiusE M Shooter
Aug 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·R C KowalM S Brown
Jan 1, 1988·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·J DavignonC F Sing
Jan 1, 1983·Methods in Enzymology·J L GoldsteinM S Brown
Feb 1, 1995·Ophthalmology·J R VingerlingP T de Jong
May 1, 1994·Nature Genetics·C M van DuijnC Van Broeckhoven
Jan 1, 1994·Atherosclerosis·K KervinenY A Kesäniemi
Mar 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·W J StrittmatterA D Roses
Jan 1, 1996·American Journal of Ophthalmology·K W SmallK Gehrs
Dec 1, 1995·Annals of Medicine·J PoirierJ Davignon
Jan 15, 1997·Microscopy Research and Technique·M KliffenP T de Jong
Feb 1, 1997·American Journal of Ophthalmology·J M SeddonB D Mitchell

❮ Previous
Next ❯

Citations

Sep 20, 2005·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·H P N SchollF G Holz
Feb 22, 2011·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Shani GolanAnat Loewenstein
Jul 31, 2007·Human Genetics·Andrew Lotery, Dorothy Trump
Mar 21, 2007·Angiogenesis·Albert O Edwards, Goldis Malek
Mar 8, 2005·Survey of Ophthalmology·Robyn Heather GuymerPaul Nigel Baird
Sep 5, 2002·American Journal of Ophthalmology·Don H AndersonLincoln V Johnson
Dec 10, 2002·American Journal of Ophthalmology·Tien Yin WongA Richey Sharrett
Nov 6, 2002·Clinica Chimica Acta; International Journal of Clinical Chemistry·Jean-Hervé AbalainJoseph Colin
May 15, 2003·Survey of Ophthalmology·Jayakrishna AmbatiAnthony P Adamis
Feb 15, 2001·Progress in Retinal and Eye Research·J R Evans
Oct 4, 2002·Comptes rendus biologies·Philippe Amouyel
Jul 14, 2001·Eye·P T De JongJ M Assink
Mar 5, 2013·Nature Genetics·Lars G FritscheUNKNOWN AMD Gene Consortium
Jan 24, 2012·Nature Neuroscience·Sandra SiegertBotond Roska
Jun 16, 2012·Nature Reviews. Drug Discovery·Kang ZhangRobert N Weinreb
Oct 6, 2006·The New England Journal of Medicine·Paulus T V M de Jong
Apr 19, 2011·American Journal of Epidemiology·Gareth J McKayChris C Patterson
Oct 9, 2002·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Robyn Guymer
Nov 4, 2010·Molecular Interventions·Yuhong ChenKang Zhang
Mar 20, 2004·The British Journal of Ophthalmology·A JünemannJ Kornhuber
Mar 20, 2004·The British Journal of Ophthalmology·S LakeJ F Salmon
Apr 20, 2004·The British Journal of Ophthalmology·M ZetterbergK Höglund
May 26, 2006·The British Journal of Ophthalmology·N DashtiC A Curcio
Nov 25, 2000·The British Journal of Ophthalmology·M KliffenP T de Jong
Jun 26, 2001·The British Journal of Ophthalmology·C MunautJ M Rakic
Sep 6, 2011·The British Journal of Ophthalmology·Christine A CurcioJiahn-Dar Huang
Feb 9, 2000·Journal of Medical Genetics·J R Yates, A T Moore
Sep 10, 2003·Journal of Medical Genetics·M MichaelidesA T Moore
Jan 1, 2009·Journal of Ophthalmology·Paul P ConnellStephen Beatty
Dec 5, 2012·Mediators of Inflammation·Francesco ParmeggianiAdolfo Sebastiani
Jul 24, 2012·The Journal of Clinical Investigation·Saida OmarovaIrina A Pikuleva
Oct 3, 2009·Journal of Lipid Research·Christine A CurcioMartin Rudolf
Jun 6, 2012·PloS One·Felix GrassmannBernhard H F Weber
Dec 24, 2010·Clinical Chemistry and Laboratory Medicine : CCLM·Haris KokotasMichael B Petersen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Alzheimer's Disease: APOE

Apolipoprotein E (APOE) polymorphic alleles are major genetic risk factors for Alzheimer's disease. Discover the latest research on APOE and other genetic determinants of Alzheimer's disease here.

Astrocytes & Neurodegeneration

Astrocytes are important for the health and function of the central nervous system. When these cells stop functioning properly, either through gain of function or loss of homeostatic controls, neurodegenerative diseases can occur. Here is the latest research on astrocytes and neurodegeneration.

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

ApoE Phenotypes

Apolipoprotein E (APOE) is a protein involved in fat metabolism and associated with the pathogenesis of Alzheimer's disease and cardiovascular disease. Here is the latest research on APOE phenotypes.

Alzheimer's Disease: Genetics

Alzheimer's disease is a neurodegenerative disease. Discover genetic and epigenetic aspects of Alzheimer’s disease, including genetic markers and genomic structural variations with this feed.