Oct 26, 2018

Genetic Association of Arterial Stiffness Index with Blood Pressure and Coronary Artery Disease

BioRxiv : the Preprint Server for Biology
Seyedeh M ZekavatPradeep Natarajan

Abstract

Background: Arterial stiffness index (ASI) is independently associated with blood pressure and coronary artery disease (CAD) in epidemiologic studies. However, it is unknown whether these associations represent causal relationships. Objectives: Here, we assess whether genetic predisposition to increased ASI is associated with elevated blood pressure and CAD risk. Methods: Genome-wide association analysis (GWAS) of finger photoplethysmography-derived ASI was performed in 131,686 participants from the UK Biobank. Across UK Biobank participants not in the ASI GWAS, a 6-variant ASI polygenic risk score was calculated. The ASI polygenic score was associated with systolic and diastolic blood pressures (SBP, DBP, N=208,897), and with incident CAD over 10 years follow-up (N=223,061; 7,534 cases). The lack of CAD association observed was replicated among 184,305 participants (60,810 cases) from the Coronary Artery Disease Genetics Consortium (CARDIOGRAMplusC4D). Results: We replicated prior reports of the epidemiologic association of ASI with SBP (Beta 0.55mmHg, [95% CI, 0.45-0.65], P=5.77x10-24), DBP (Beta 1.05mmHg, [95% CI, 0.99-1.11], P=7.27x10-272), and incident CAD (HR 1.08 [95% CI, 1.04-1.11], P=1.5x10-6) in multivariable models. ...Continue Reading

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Mentioned in this Paper

Genome-Wide Association Study
Diastolic Blood Pressure Measurement
FOXO1 gene
Follow-up
Coronary Artery Disease
RNF126 gene
Systolic Blood Pressure Measurement
Diastolic Blood Pressure
Human Genetics
COL4A2 gene

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