PMID: 3759225Oct 1, 1986Paper

Genetic association of hypertension and vascular changes in stroke-prone spontaneously hypertensive rats

Hypertension
C A BrunerR C Webb

Abstract

Isolated tail arteries from stroke-prone spontaneously hypertensive rats (SHRSP) exhibit oscillatory contractile activity in response to norepinephrine, whereas those from normotensive Wistar-Kyoto rats (WKY) do not. To determine whether the norepinephrine-induced oscillations are related to high blood pressure or to separable genetic differences between strains, the response to norepinephrine was studied in adult SHRSP, WKY, and progeny of genetic crosses of SHRSP and WKY (F1, F2, F1 X SHRSP, F1 X WKY). Helical tail artery strips were mounted in a tissue bath for isometric force recording. Rats were classified as responders if oscillatory activity in the presence of 1.8 X 10(-7) M norepinephrine exceeded 250 mg/10 min (milligrams of force amplitude during a 10-minute interval). The blood pressures (mm Hg +/- SEM; tail cuff method) and percentage of rats exhibiting norepinephrine-induced oscillations were as follows: WKY: 109 +/- 3, 0%; F1: 129 +/- 4, 0%; F2: 150 +/- 4, 38%; F1 X WKY: 137 +/- 3, 9%; F1 X SHRSP: 188 +/- 7, 71%; SHRSP: 207 +/- 7, 100%. The distribution of the frequency of animals with oscillatory activity among the progenies was consistent with the hypothesis that a single gene locus determines the observed diffe...Continue Reading

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Citations

Aug 1, 1988·Computers and Biomedical Research, an International Journal·G AvinashC A Rawlings
May 4, 1999·Clinical and Experimental Pharmacology & Physiology·K ShimamuraS Sunano
Apr 19, 2011·Cardiovascular Research·Torbjoern BroeggerVladimir V Matchkov
Jan 1, 1995·Clinical and Experimental Pharmacology & Physiology. Supplement·M HamanoT Tomita
Jan 1, 1988·Clinical and Experimental Hypertension. Part A, Theory and Practice·B G Yongue, M M Myers
Jan 1, 1991·Clinical and Experimental Hypertension. Part A, Theory and Practice·G Schlager, C S Chao
Jan 1, 1987·Clinical and Experimental Hypertension. Part A, Theory and Practice·C A Bruner, R C Webb
Jan 1, 1992·Clinical Physiology·R C WebbS M Papadopoulos
Sep 1, 1986·The Proceedings of the Nutrition Society·A F Lever
Oct 5, 2006·American Journal of Physiology. Renal Physiology·Susanne DitlevsenNiels-Henrik Holstein-Rathlou
Oct 3, 1999·Physiological Reviews·J Zicha, J Kunes

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