Genetic association of RIT2 rs12456492 polymorphism and Parkinson's disease susceptibility in Asian populations: a meta-analysis

Scientific Reports
Yanjun LuXiong Wang

Abstract

Recent studies investigating the association of the Ras-like without CAAX 2 (RIT2) polymorphism, rs12456492, with Parkinson's disease (PD) are controversial. We performed a meta-analysis to study the association between rs12456492 and PD susceptibility in Asian populations. Literature searches of PubMed and Embase were performed up to June 3, 2015, and the strength of the association between rs12456492 and PD was evaluated by odds ratios (OR) and 95% confidence intervals (CI). Four studies conducted between 2013 and 2015, comprising 2017 PD cases and 2010 controls, were included in the meta-analysis. Significant association of rs12456492 with PD was found in the dominant (GG + AG vs. AA: OR = 1.26, 95% CI = 1.20-1.44, P = 0.00) and additive models (GG vs. AA: OR = 1.38, 95% CI = 1.03-1.83, P = 0.030). Although sensitivity analysis found that the overall result was stable only in the dominant genetic model, a publication bias was also detected. Therefore, the results should be treated with caution. The current meta-analysis suggested that rs12456492 might be associated with increased PD risk in Asian populations, but studies using larger sample sizes and different ethnic populations will be needed to further confirm this associa...Continue Reading

References

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Citations

Mar 5, 2016·Molecular Neurobiology·Babak EmamalizadehHossein Darvish
Jun 4, 2018·Molecular Genetics and Genomics : MGG·Yousef DaneshmandpourBabak Emamalizadeh
Nov 28, 2016·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Jun-Ying LiRong Peng
Nov 23, 2017·Frontiers in Molecular Neuroscience·Ahmad R ArshadNor Azian Abdul Murad
Feb 13, 2017·Metabolic Brain Disease·Shima Yazdandoost HamedaniMohammad Taheri
May 29, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Ali KhodadadianMahta Mazaheri

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