Genetic association of the activin A receptor gene (ACVR2A) and pre-eclampsia.

Molecular Human Reproduction
E FitzpatrickE K Moses

Abstract

Pre-eclampsia is a common serious disorder of human pregnancy, which is associated with significant maternal and perinatal morbidity and mortality. The suspected aetiology of pre-eclampsia is complex, with susceptibility being attributable to multiple environmental factors and a large genetic component. Recently, we reported significant linkage to chromosome 2q22 in 34 Australian/New Zealand (Aust/NZ) pre-eclampsia/eclampsia families, and activin A receptor type IIA (ACVR2A) was identified as a strong positional candidate gene at this locus. In an attempt to identify the putative risk variants, we have now comprehensively re-sequenced the entire coding region of the ACVR2A gene and the conserved non-coding sequences in a subset of 16 individuals from these families. We identified 45 single nucleotide polymorphisms (SNPs), with 9 being novel. These SNPs were genotyped in our total family sample of 480 individuals from 74 Aust/NZ pre-eclampsia families (including the original 34 genome-scanned families). Our best associations between ACVR2A polymorphisms and pre-eclampsia were for rs10497025 (P = 0.025), rs13430086 (P = 0.010) and three novel SNPs: LF004, LF013 and LF020 (all with P = 0.018). After correction for multiple hypothe...Continue Reading

References

Jun 1, 1976·British Journal of Preventive & Social Medicine·J I MannW E Waters
Jan 1, 1975·Mechanisms of Ageing and Development·H Tauchi, T Sato
Mar 1, 1968·Obstetrics and Gynecology·C W Curl, W L Johnson
Apr 1, 1995·Human Molecular Genetics
Feb 1, 1995·The Journal of Clinical Endocrinology and Metabolism·F PetragliaT K Woodruff
Aug 1, 1993·The Journal of Clinical Endocrinology and Metabolism·F PetragliaW Vale
Nov 1, 1995·Acta Obstetricia Et Gynecologica Scandinavica·L S JónsdóttirN Sigfússon
Feb 1, 1996·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·T F Mackay
Jan 1, 1997·Annual Review of Medicine·A G Witlin, B M Sibai
May 23, 1998·American Journal of Human Genetics·L Almasy, J Blangero
Jun 6, 1998·BMJ : British Medical Journal·R T LieL M Irgens
Aug 5, 1998·American Journal of Reproductive Immunology : AJRI·R F FraserP Coney
Aug 11, 1999·Human Molecular Genetics·R ArngrímssonK Stefánsson
Dec 28, 1999·British Journal of Obstetrics and Gynaecology·H LaivuoriO Ylikorkala
Feb 26, 2000·Metabolism: Clinical and Experimental·H LaivuoriO Ylikorkala
Apr 15, 2000·American Journal of Medical Genetics·H Salonen RosS Cnattingius
Jun 10, 2000·BJOG : an International Journal of Obstetrics and Gynaecology·C A HubelR Arngrímsson
Jun 30, 2000·Human Reproduction·S MuttukrishnaC W Redman
Jul 26, 2000·European Journal of Human Genetics : EJHG·G R AbecasisL R Cardon
Aug 29, 2000·Obstetrics and Gynecology·W A Grobman, E Y Wang
Oct 4, 2000·Nature Genetics·K M Weiss, J D Terwilliger
Apr 13, 2001·JAMA : the Journal of the American Medical Association·J C ChambersJ S Kooner
Nov 24, 2001·BMJ : British Medical Journal·H U IrgensR T Lie
Jan 10, 2002·European Journal of Human Genetics : EJHG·A M LachmeijerK Stéfansson
Jun 14, 2002·Placenta·J M Roberts, K Y Lain
Jul 20, 2002·BMJ : British Medical Journal·Naveed Sattar, Ian A Greer
Aug 6, 2002·The Journal of Clinical Endocrinology and Metabolism·Rebecca L JonesJock K Findlay
Mar 8, 2003·Hypertension·James M RobertsUNKNOWN NHLBI Working Group on Research on Hypertension During Pregnancy
Dec 23, 1961·Lancet·E M ADAMS, A FINLAYSON
Dec 23, 1961·Lancet·E M ADAMS, I MACGILLIVRAY
Feb 14, 2004·BJOG : an International Journal of Obstetrics and Gynaecology·Emma NilssonPaul Lichtenstein
Mar 17, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Patricia K AgatisaMargaret K McLaughlin
Feb 11, 2005·Epidemiology·Edmund F FunaiSusan Harlap
Sep 6, 2005·Science·P CarninciUNKNOWN RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Sep 15, 2005·American Journal of Obstetrics and Gynecology·Darcy B CarrCathy W Critchlow
Oct 19, 2005·Hypertension·James M Roberts, Hilary S Gammill

❮ Previous
Next ❯

Citations

Jul 7, 2009·Human Genetics·Matthew P JohnsonEric K Moses
Dec 12, 2012·Pharmacogenomics and Personalized Medicine·Paula Juliet Williams, Linda Morgan
Feb 18, 2016·Human Reproduction Update·R Wijayarathna, D M de Kretser
May 15, 2013·Medical Hypotheses·Sonia T ChelbiDaniel Vaiman
Mar 25, 2011·Best Practice & Research. Clinical Obstetrics & Gynaecology·Paula J Williams, Fiona Broughton Pipkin
Dec 17, 2014·Cytokine·Rachel D WilliamsonLouise C Kenny
Mar 12, 2019·Genetics and Molecular Biology·Damian WodzińskiEwa Balcerczak
Mar 10, 2019·The Journal of Heredity·Christian J PosberghHeather J Huson
Feb 15, 2017·Cold Spring Harbor Perspectives in Biology·Diana MonsivaisStephanie A Pangas
Mar 7, 2018·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Andrey S GlotovVladislav S Baranov

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.