Oct 30, 2018

Genetic Association of The CYP7A1 Gene with Duck Lipid Traits

BioRxiv : the Preprint Server for Biology
Yu Yi ZhangLei Wu

Abstract

Cholesterol 7α-hydroxylase (Cyp7a1) participates in lipid metabolism of liver, and its pathway involves catabolism of cholesterol to bile acids and excretion from the body. However, little is known about the effect of the polymorphisms of CYP7A1 gene on duck lipid traits. In the present study, seven novel synonymous mutations loci in exon 2 and exon 3 of CYP7A1 gene in Cherry Valley ducks were identified using PCR production direct sequencing. One novel SNP g.1033130 C>T was predicted in exon 2. Six novel SNPs g.1034076 C>T, g.1034334 G>A, g.1034373 G>A, g.1034448 T>C, g.1034541 C>G, and g.1034550 G>A were discovered in exon 3. Six haplotypes were detected using SHEsis online analysis software, and five loci (g.1034334G>A, g.1034373G>A, g.1034448T>C, g.1034541C>G, and g.1034550G>A) were in complete linkage disequilibrium, and as a block named Locus C3. By single SNP association analysis, we found that the g.1033130 C>T locus was significantly associated with IMF, AFP, TG, and TC ( P <0.01 or P <0.05) respectively, the g.1034076 C>T locus was significantly associated with AFP (P<0.05), and the locus C3 was significantly associated with TCH ( P <0.05). Sixteen dipoltypes were detected by the combination of haplotypes, and demonst...Continue Reading

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Mentioned in this Paper

Biological Markers
Gene Polymorphism
Study
Biochemical Pathway
Inframammary Fold
C3 gene
Bile Acid Measurement
Block Dosage Form
Area TG of Bonin
CYP7A1

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