Genetic association of TLR4 Asp299Gly, TLR4 Thr399Ile, and CD14 C-159T polymorphisms with the risk of severe RSV infection: a meta-analysis

Influenza and Other Respiratory Viruses
Jiahui ZhouZunnan Huang

Abstract

Respiratory syncytial virus (RSV) is the most frequent cause of hospitalization in infants worldwide. It is recognized by Toll-like receptor 4 (TLR 4) and cluster of differentiation 14 (CD14) in the innate immune response. Previous case-control studies reported the influence of TLR4 Asp299Gly, TLR4 Thr399Ile, and CD14 C-159T polymorphisms on the risk of severe RSV infection. However, a decisive conclusion has not been achieved. Therefore, we performed this meta-analysis to examine the association between these three polymorphisms and the development of RSV bronchiolitis. A systematic literature search was performed using the PubMed, EMbase, Google Scholar Search, China National Knowledge Infrastructure, China Biological Medicine, and Wanfang Databases. The data were extracted and pooled odds ratios with 95% confidence intervals were calculated under six genetic models. A total of six studies with 1009 cases and 1348 controls, three studies with 473 cases and 481 controls, or four studies with 325 cases and 650 controls relating to each of the three polymorphisms were included in this meta-analysis. The analyzed data indicated that all of these polymorphisms were not associated with the risk of severe RSV infection. This is the ...Continue Reading

References

Jun 1, 1986·American Journal of Diseases of Children·W P GlezenJ A Kasel
Mar 10, 1999·The American Journal of Physiology·K IkejimaR G Thurman
Mar 29, 2002·Journal of Medical Virology·James M StarkGeorge D Leikauf
Jul 12, 2002·Statistics in Medicine·Julian P T Higgins, Simon G Thompson
May 23, 2003·American Journal of Respiratory Cell and Molecular Biology·Philomena M Kaan, Richard G Hegele
Sep 6, 2003·BMJ : British Medical Journal·Julian P T HigginsDouglas G Altman
May 15, 2004·The Journal of Infectious Diseases·Guy TalNinette Amariglio
Aug 31, 2004·Pediatric Pulmonology·Tessa GoetghebuerJeremy Hull
Feb 1, 2007·Disease Markers·Beena PuthothuMarcus Krueger
Apr 24, 2007·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Stéphane C PaulusStuart E Turvey
Mar 6, 2009·PLoS Medicine·Gurdeep S SagooJulian P T Higgins
Feb 2, 2010·Paediatric Respiratory Reviews·Claire Wainwright
Jun 25, 2010·Pediatric Pulmonology·Johan LöfgrenMikko Hallman
Aug 16, 2011·Molecular Medicine Reports·Song-Quan WuCong Chen
Jan 15, 2014·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jonathan M CiencewickiSteven R Kleeberger
Jun 22, 2014·Molecular Immunology·Marco Di Gioia, Ivan Zanoni
Jan 13, 2015·International Journal of Immunopathology and Pharmacology·M GoutakiM Hatzistylianou

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Citations

Jan 22, 2018·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Kirsten C VerheinSteven R Kleeberger
Aug 31, 2017·Annual Review of Genetics·Adam D KenneyJacob S Yount
Jan 5, 2019·Reviews in Medical Virology·Alireza TahamtanVahid Salimi
Dec 20, 2017·Molecular Medicine Reports·Xu-Wei TaoHan-Chu Liu

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