PMID: 22587511May 17, 2012Paper

Genetic association studies in diabetic nephropathy

Current Diabetes Reviews
Harvest F Gu, Kerstin Brismar

Abstract

Clinical observations and epidemiological studies have shown that there is familial aggregation of diabetic nephropathy in many ethnic groups, indicating the strong contribution of inherited factors in the development of diabetic nephropathy. Identification of the genes involved in the pathogenesis of diabetic nephropathy may provide better knowledge of its pathophysiology and future therapies. To search for the genes involved in susceptibility, resistance or progression to diabetic nephropathy, candidate gene population association, family-based association and genome wide association studies have been widely used. This article reviews genetic polymorphisms, summarizes the data from genetic association studies of diabetic nephropathy in both type 1 and type 2 diabetes, and discusses about the future genetic analyses in the complex diseases.

Citations

Dec 25, 2012·Yi chuan = Hereditas·Jun-Yan LiHao Lu
Jun 4, 2014·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Matthew G SampsonMatthias Kretzler
Jan 26, 2016·Kidney International·Keizo Kanasaki
Jun 25, 2019·Frontiers in Genetics·Harvest F Gu

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