Genetic association study of the GNB3 C825T, the ACE I/D and the eNOS G894T polymorphisms and the risk to develop erectile dysfunction in a German ED population

Andrologia
A EisenhardtH Sperling

Abstract

Erectile dysfunction (ED) is often associated with cardiovascular disorders such as hypertension, coronary heart disease, hypercholesterolaemia and diabetes mellitus. The genotypes in the GNB3 C825T, the ACE I/D and the eNOS G894T polymorphisms have been identified as genetic risk factors for cardiovascular disorders. The association between the genotypes in these polymorphisms and the risk to develop ED was analysed. In 455 German ED patients and 111 age-matched healthy controls genotyping in the candidate polymorphisms was performed after DNA extraction from whole blood. Association studies between the genotype distribution in the control group in comparison with the ED-group and age of onset of the disease as well as erectile response to intracorporal prostaglandin injection in dependence of candidate polymorphism genotype were performed using the SPSS-Software(R). Genotype distribution of the GNB3 C825T, the ACE I/D and the eNOS G894T polymorphisms was similar in the ED population and the healthy control group. The age of onset of the disease as well as the erectile response to intracorporal prostaglandin injection was independent of the genotypes in the three candidate polymorphisms. In contrast to the previous studies in ...Continue Reading

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Citations

Sep 25, 2012·The Journal of Urology·Natalya A Lopushnyan, Kanchan Chitaley
Aug 13, 2011·The Journal of Sexual Medicine·Monica L AndersenSergio Tufik
Feb 7, 2012·The Journal of Sexual Medicine·Yung-Chin LeeChun-Hsiung Huang
May 6, 2015·The Journal of Sexual Medicine·Chunhui LiuBin Xu
Jan 10, 2012·European Journal of Clinical Investigation·Michel P HermansMichel F Rousseau
May 20, 2015·Der Urologe. Ausg. A·A EisenhardtH Rübben
Apr 4, 2017·The Journal of Sexual Medicine·Yung-Chin LeeChia-Chu Liu

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