Genetic associations in PLEKHA7 and COL11A1 with primary angle closure glaucoma: a meta-analysis

Clinical & Experimental Ophthalmology
Ping ShuaiBo Gong

Abstract

Single nucleotide polymorphisms (SNPs) rs11024102 in PLEKHA7 and rs3753841 in COL11A1 were identified to be associated with primary angle closure glaucoma (PACG) by a recent large genome-wide association study. This present study is to evaluate the association of PLEKHA7 rs11024102 and COL11A1 rs3753841 with PACG. A systematic review and meta-analysis. A total of 25 271 subjects (4895 PACG patients and 20 376 controls) in different ethnicities were tested for PLEKHA7 rs11024102 and COL11A1 rs3753841. A comprehensive literature search was conducted on studies published up to July 2014. Summary odds ratios (ORs) and 95% confidence intervals were analysed. Publication bias of the included articles was evaluated using funnel plots and Egger's test. OR for the effects of PLEKHA7 rs11024102 and COL11A1 rs3753841 on PACG risk. Four eligible articles were included in this study for meta-analysis. The overall result showed that SNPs rs11024102 and rs3753841 were statistically associated with PACG (P < 0.001) in fixed-effects model. Stratified analyses showed that the association of PLEKHA7 rs11024102 and COL11A1 rs3753841 with PACG was statistically significant in Asian population (including South Indian cohort) (P < 0.001). In Caucasia...Continue Reading

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Citations

Mar 18, 2021·The Application of Clinical Genetics·Altaf A Kondkar
Jun 20, 2020·Biochimica Et Biophysica Acta. Biomembranes·Florian RouaudSandra Citi

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