Genetic background in patients with acute myocardial infarction

Japanese Heart Journal
S AokiT Katagiri

Abstract

The renin-angiotensin system is believed to play important roles in the development of acute myocardial infarction, and gene polymorphisms may also be involved. To investigate the genetic background in patients with acute myocardial infarction, we performed a case control study in a Japanese population. The study included 150 patients with acute myocardial infarction and 150 healthy, age- and sex-matched controls. We examined polymorphisms of angiotensin II type 1 receptor (1 166 A / C), type 2 receptor (3123 C / A), and bradykinin B2 receptor (-58 T / C) in these subjects. The allelic frequencies of angiotensin II type I receptor C and angiotensin II type 2 receptor A were significantly higher in the acute myocardial infarction subjects than in the control subjects, and this tendency was more significant in the younger patients. The combined ratios of angiotensin II type 1 receptor C and type 2 receptor A alleles in patients under 64 years old were significantly higher than in their older counterparts. However the total numbers of conventional coronary risk factors (hypertension, hypercholesterolemia, diabetes mellitus, and smoking) in individual subjects were not significantly different between younger and older patients. The...Continue Reading

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Citations

Jul 14, 2010·European Journal of Medical Genetics·Gilles MillatRobert Rousson
Aug 8, 2012·Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre·Kazuhiko KotaniNobuyuki Taniguchi
Jul 22, 2008·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Amy K MottlKari E North
Apr 18, 2013·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Djabaria Naïma MeroufelThierry Brousseau

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