Genetic basis for susceptibility to noise-induced hearing loss in mice

Hearing Research
R R DavisL C Erway

Abstract

The C57BL/6J (B6) and DBA/2J (D2) inbred strains of mice exhibit an age-related hearing loss (AHL) due to a recessive gene (Ahl) that maps to Chromosome 10. The Ahl gene is also implicated in the susceptibility to noise-induced hearing loss (NIHL). The B6 mice (Ahl/Ahl) are more susceptible to NIHL than the CBA/CaJ (CB) mice (+(Ahl)). The B6xD2.F(1) hybrid mice (Ahl/Ahl) are more susceptible to NIHL than the CBxB6.F(1) mice (+/Ahl) [Erway et al., 1996. Hear. Res. 93, 181-187]. These genetic effects implicate the Ahl gene as contributing to NIHL susceptibility. The present study demonstrates segregation for the putative Ahl gene and mapping of such a gene to Chromosome 10, consistent with other independent mapping of Ahl for AHL in 10 strains of mice [Johnson et al., 2000. Genomics 70, 171-180]. The present study was based on a conventional cross between two inbred strains, CBxB6.F(1) backcrossed to B6 with segregation for the putative +/Ahl:Ahl/Ahl. These backcross progeny were exposed to 110 dB SPL noise for 8 h. All of the progeny were tested for auditory evoked brainstem responses and analyzed for any significant permanent threshold shift of NIHL. Cluster analyses were used to distinguish the two putative genotypes, the leas...Continue Reading

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Citations

Dec 3, 2003·Journal of the Association for Research in Otolaryngology : JARO·Ralph H Holme, Karen P Steel
Jun 15, 2011·Journal of the Association for Research in Otolaryngology : JARO·Ryan J Longenecker, Alexander V Galazyuk
Feb 5, 2004·Hearing Research·Elizabeth M KeithleyKenneth R Johnson
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Apr 23, 2009·Lab Animal·Amanda M LauerJulie Watson
Apr 25, 2007·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Anne ViljanenTaina Rantanen
Oct 22, 2009·Pigment Cell & Melanoma Research·Silvia Murillo-CuestaLluís Montoliu
Apr 24, 2007·Archives of Environmental & Occupational Health·Jingqiao LuYiming Zhao
Jan 20, 2011·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Yong CuiKaoru Ogawa
Dec 5, 2012·Mutation Research·Mariola Sliwinska-Kowalska, Malgorzata Pawelczyk
Dec 27, 2015·Hearing Research·Anthony MyintRick A Friedman
Nov 10, 2010·Neurobiology of Disease·Jeremy M SullivanSharon Oleskevich
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May 24, 2003·Annals of the New York Academy of Sciences·Gary E ShullVikram Prasad
Oct 31, 2008·Journal of Biochemical and Molecular Toxicology·Ci MaMary Beth Genter
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Apr 7, 2005·Hearing Research·Per-Inge CarlssonGuy Van Camp
Apr 4, 2007·International Journal of Occupational Medicine and Environmental Health·Mariola Sliwińska-KowalskaAnna Gajda-Szadkowska
Sep 1, 2004·Biochemical and Biophysical Research Communications·Vikram PrasadGary E Shull
Feb 13, 2007·Biochemical and Biophysical Research Communications·Yuka MoritaRyo Kominami

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