Genetic biomarkers for hepatocellular cancer risk in a caucasian population

World Journal of Gastroenterology : WJG
Elena De MattiaGiuseppe Toffoli

Abstract

To uncover novel genetic markers that could contribute to predicting hepatocellular carcinoma (HCC) susceptibility in Caucasians. The present retrospective case-control study compared genotype frequencies between a cohort of HCC cases and two, independent, HCC-free, age/sex-matched control groups. The HCC cohort comprised 192 homogeneous patients that had undergone orthotopic liver transplantation. The first control group comprised 167 patients that were matched to the HCC cohort for the percentage of hepatitis B (HBV) and/or hepatitis C (HCV) infections. A second control group included 192 virus-free, healthy individuals that were used to evaluate the generalizability of the identified predictive markers. All cases and controls were Caucasian. The three study populations were characterized with a panel of 31 markers derived from 21 genes that encoded key proteins involved in hepatocarcinogenesis-related pathways. The study end-point was to assess the association between genetic variants and HCC onset. Five genetic markers were identified as risk factors for HCC in high-risk patients infected with HBV/HCV. According to a dominant model, reduced HCC risk was associated with three polymorphisms: ERCC1 rs3212986 (OR = 0.46, 95%CI:...Continue Reading

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Citations

Mar 21, 2019·Radiology and Oncology·Kristina LevpuscekAlenka Franko
Aug 16, 2019·World Journal of Gastroenterology : WJG·Elena De MattiaGiuseppe Toffoli
Nov 7, 2019·International Journal of Molecular Sciences·Silvia MezzaliraGiuseppe Toffoli
Jun 27, 2019·The Journal of International Medical Research·Qing ChangXiao-Hui Zhao
Feb 23, 2021·Biochemical and Biophysical Research Communications·Yihua ChenMinghua Qi
Jul 10, 2021·World Journal of Hepatology·Vasyl PrysyazhnyukPetro Prysyazhnyuk
Oct 2, 2021·PloS One·Zahraa I KhamisJinfeng Zhang

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Methods Mentioned

BETA
PCR
genotyping
electrophoresis

Software Mentioned

SAS

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