Genetic bottlenecks reduce population variation in an experimental RNA virus population

Journal of Virology
Hongye Li, Marilyn J Roossinck

Abstract

Genetic bottlenecks are stochastic events that limit genetic variation in a population and result in founding populations that can lead to genetic drift. Evidence of past genetic bottlenecks in numerous biological systems, from mammals to viruses, has been described. In this study, we used an artificial population of Cucumber mosaic virus consisting of 12 restriction enzyme marker-bearing mutants. This population was inoculated onto young leaves of tobacco plants and monitored throughout the course of systemic infection. We show here that the genetic variation in a defined population of an RNA virus is significantly, stochastically, and reproducibly reduced during the systemic infection process, providing clear evidence of a genetic bottleneck.

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Citations

Sep 15, 2010·Journal of Molecular Evolution·Israel PagánEdward C Holmes
Jun 16, 2010·Virus Genes·Beata Hasiów-JaroszewskaHenryk Pospieszny
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Aug 17, 2006·Journal of Virology·Akhtar AliMarilyn J Roossinck
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