Genetic changes found in a distinct clade of Enterovirus D68 associated with paralysis during the 2014 outbreak

Virus Evolution
Yun ZhangRichard H Scheuermann

Abstract

Enterovirus D68 (EV-D68) caused a severe respiratory illness outbreak in the United States in 2014. Reports of acute flaccid myelitis (AFM)/paralysis (AFP) in several independent epidemiological clusters of children with detectable EV-D68 have raised concerns that genetic changes in EV-D68 could be causing increased disease severity and neurological symptoms. To explore the potential link between EV-D68 genetic variations and symptom changes, we performed a series of comparative genomic analyses of EV-D68 2014 outbreak isolate sequences using data and analytical tools in the Virus Pathogen Resource (ViPR; www.viprbrc.org). Our results suggest that (1) three distinct lineages of EV-D68 were co-circulating in 2013 and 2014; (2) isolates associated with AFM/AFP belong to a single phylogenetic subclade - B1; (3) the majority of isolates from the B1 subclade have 21 unique substitutions that distinguish them from other isolates, including amino acid substitutions in the VP1, VP2, and VP3 capsid proteins and the 3D RNA-dependent RNA polymerase, and nucleotide substitutions in the internal ribosome entry sequence (IRES); (4) at 12 of these positions, B1 isolates carry the same residues observed at equivalent positions in paralysis-cau...Continue Reading

References

Mar 1, 1967·American Journal of Epidemiology·J H SchiebleE H Lennette
Mar 19, 1996·Proceedings of the National Academy of Sciences of the United States of America·M GromeierE Wimmer
Mar 23, 2004·Nucleic Acids Research·Robert C Edgar
Apr 29, 2005·Journal of Virology·Stephanie A CampbellMatthias Gromeier
Oct 9, 2007·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Joe ParkerOliver G Pybus
Oct 19, 2011·Nucleic Acids Research·Brett E PickettRichard H Scheuermann
Jun 15, 2012·The Journal of General Virology·Rafal TokarzW Ian Lipkin
Mar 8, 2014·Journal of Biomedical Science·Jing-Yi Lin, Shin-Ru Shih
Nov 14, 2014·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·M LangH Peigue-Lafeuille
Dec 24, 2014·Influenza and Other Respiratory Viruses·Karoline BragstadAnne-Marte B Kran
Jul 26, 2015·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Avram LevyDavid J Speers
Jan 1, 2016·JAMA : the Journal of the American Medical Association·Keith Van HarenCarol A Glaser
Jan 26, 2016·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·Danuta M SkowronskiMel Krajden

❮ Previous
Next ❯

Citations

Mar 20, 2019·Journal of the Pediatric Infectious Diseases Society·Janet R Gilsdorf
Apr 4, 2019·MBio·David M MorensAnthony S Fauci
Feb 14, 2019·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·UNKNOWN The United Kingdom Acute Flaccid Paralysis Afp Task Force
Jul 20, 2019·Nature Communications·Jim BaggenFrank J M van Kuppeveld
Jul 1, 2018·Current Infectious Disease Reports·Ari Bitnun, E Ann Yeh
Sep 20, 2018·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·Rolf KramerLaurence Josset
Sep 24, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Andrea M LernerEmily Erbelding
Dec 2, 2020·Microorganisms·David M BrownRichard H Scheuermann
Jan 24, 2021·The Journal of Biological Chemistry·Matthew J ElrickPriya Duggal
May 18, 2021·Journal of Medical Microbiology·Ramachandran Erathodi SanjayGovindakarnavar Arunkumar
Jul 10, 2021·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Yulu FangChangzheng Dong
Aug 20, 2021·Virulence·Syriam Sooksawasdi Na AyudhyaDebby van Riel
May 1, 2020·ACS Infectious Diseases·Yanmei HuJun Wang

❮ Previous
Next ❯

Methods Mentioned

BETA
AFM
genotyping

Software Mentioned

Bayesian Evolutionary Analysis Utility ( BEAUTi )
BEAST Tip - association Significance ( BaTS )
Bayesian Evolutionary Analysis Sampling Trees ( BEAST )
ViPR
Jalview
RAxML
Clustal
ViPR meta - CATS
BaTS

Related Concepts

Related Feeds

CZI Human Cell Atlas Seed Network

The aim of the Human Cell Atlas (HCA) is to build reference maps of all human cells in order to enhance our understanding of health and disease. The Seed Networks for the HCA project aims to bring together collaborators with different areas of expertise in order to facilitate the development of the HCA. Find the latest research from members of the HCA Seed Networks here.