PMID: 11900846Mar 20, 2002Paper

Genetic characterization and phylogeny of human T-cell lymphotropic virus type I from Chile

Virus Research
E RamirezJ Fernandez

Abstract

Infection with Human T-Cell Lymphotropic Virus type I (HTLV-I) have been associated with the development of the HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP). Phylogenetic analyses of HTLV-I isolates have revealed that HTLV-I can be classified into three major groups: the Cosmopolitan, Central African and Melanesian. In the present study, we analyzed the tax, 5' ltr, gag, pol, and env sequences of proviruses of PBMC from ten HAM/TSP patients to investigate the phylogenetic characterization of HTLV-I in Chilean patients. HTLV-I provirus in PBMC from ten Chilean patients with HAM/TSP were amplified by PCR using primers of tax, 5' ltr, gag, pol, and env genes. Amplified products of the five genes were purified and nucleotide sequence was determined by the dideoxy termination procedure. DNA sequences were aligned with the CLUSTAL W program. The results of this study showed that the tax, 5' ltr, gag, pol, and env gene of the Chilean HTLV-I strains had a nucleotide homology ranged from 98.1 to 100%, 95 to 97%, 98.9 to 100%, 94 to 98%, and 94.2 to 98.5% respect to ATK-1 clone, respectively. According to molecular phylogeny with 5' ltr gene, the Chilean HTLV-I strains were grouped with each other suggesting one cl...Continue Reading

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Citations

Mar 28, 2012·AIDS Research and Human Retroviruses·Mariana Cavalheiro MagriAdele Caterino-de-Araujo
Mar 28, 2017·AIDS Research and Human Retroviruses·Sekh ThanprasertsukChusana Suankratay
Jul 29, 2008·AIDS Research and Human Retroviruses·René GastaldelloSandra Gallego
Dec 13, 2006·Revista Da Sociedade Brasileira De Medicina Tropical·Lucinda A SouzaAntonio Carlos R Vallinoto
Aug 21, 2021·Archives of Virology·Felipe de Oliveira AndradeFernanda Khouri Barreto

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