PMID: 2492667Feb 1, 1989Paper

Genetic characterization of FLA, the cat major histocompatibility complex

Proceedings of the National Academy of Sciences of the United States of America
C WinklerS J O'Brien

Abstract

The major histocompatibility complex (MHC) of the domestic cat (termed FLA) has been refractile to genetic and serological definition largely because of repeated failure to detect cytotoxic antibodies in multiparous cats or to elicit antibody following allogeneic lymphocyte immunization. We have developed a protocol for producing cytotoxic alloantisera in the cat following rejection of multiple surgical skin grafts. Of 59 cats subjected to grafting, 13 produced lymphocytotoxic antisera which had varying specificities among a panel of outbred cat cells. A population cluster analysis of the 13 alloantisera permitted the identification of six clusters of overlapping FLA specificities. Serological analysis of cells from 12 cat kindreds led to the definition of 24 allogeneic haplotypes, which segregate as a single Mendelian complex. Feline FLA antisera were characterized as class I or class II specific by immunoprecipitation of FLA gene products on lymphocyte cell surfaces. Abundant antigenic polymorphisms for both class I and class II MHC determinants were discovered, a result consistent with precedence in other species and the common expectation of the adaptive value of MHC variation. Development of feline MHC typing reagents and ...Continue Reading

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Citations

Jan 1, 1992·Comparative Immunology, Microbiology and Infectious Diseases·D S Lin
Dec 5, 1998·Veterinary Immunology and Immunopathology·J K YamamotoN Gengozian
Jan 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·N Yuhki, S J O'Brien
May 14, 2003·Genome Research·Naoya YuhkiStephen J O'Brien
Nov 1, 1990·Tissue Antigens·B A RideoutN C Pedersen
May 13, 2008·Veterinary Immunology and Immunopathology·F Reggeti, D Bienzle
Nov 1, 1995·Research in Veterinary Science·P HuntJ Hopkins
Feb 24, 2001·The Journal of Veterinary Medical Science·Y KuwaharaY Sasaki
Jun 24, 1999·The Journal of Veterinary Medical Science·Y KuwaharaY Sasaki
Oct 3, 2002·Annual Review of Genetics·Stephen J O'BrienNaoya Yuhki

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