Genetic characterization of Neospora caninum from Northern Italian cattle reveals high diversity in European N. caninum populations

Parasitology Research
Javier Regidor-CerrilloAlda Natale

Abstract

Recent studies have revealed extensive genetic variations among Neospora caninum, a cyst-forming protozoan parasite that is one of the main causes of bovine abortion in the cattle industry worldwide. Previous genetic studies based on multilocus microsatellite genotyping (MLGs) of different Ibero-American populations showed a high genetic diversity. These studies provided clear clues of a predominant clonal propagation in cattle and population sub-structuring partially associated with geographical origin. Although, these reports were limited to a reduced number of countries. In this study, the N. caninum isolates from aborted bovine fetuses and stillbirths and a goat abortion from Northern Italy were investigated genetically using 9 microsatellite markers. Complete or nearly complete isolate profiles were obtained from 30 fetuses and stillbirths. An extensive genetic diversity was also found in this Italian N. caninum population. The study of genetic relationships among Italian MLGs using network (eBURST) and principal component analyses based on the allele-sharing coefficient (PCoA) showed different clonal subpopulations disseminated throughout Northern Italy without apparent segregation depending on the geographic origin, catt...Continue Reading

References

Dec 5, 2003·Veterinary Parasitology·Domenico OtrantoGioia Capelli
Aug 4, 2006·The Journal of Parasitology·Javier Regidor-CerrilloLuis M Ortega-Mora
Jun 28, 2011·Veterinary Parasitology·J P Dubey, G Schares
Dec 19, 2012·International Journal for Parasitology·Michael P ReichelJohn T Ellis
Jan 21, 2014·Molecular Biology Reports·Giordano ManciniLorraine Pariset
Oct 4, 2016·Veterinary Parasitology·Leticia Medina-EsparzaCarlos Cruz-Vázquez
Oct 23, 2019·Proceedings of the National Academy of Sciences of the United States of America·Asis KhanMichael E Grigg

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Methods Mentioned

BETA
PCR
electrophoresis
genotyping
genetic exchange

Software Mentioned

LIAN
eBURST
GenAlEx

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