Genetic characterization of respiratory syncytial virus highlights a new BA genotype and emergence of the ON1 genotype in Lyon, France, between 2010 and 2014

Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology
Alexandre GaymardFlorence Morfin

Abstract

Respiratory syncytial virus (RSV) is a well-recognized cause of respiratory tract infections. Based on G gene variations, 11 RSV-A and 36 RSV-B genotypes have been described to date. The ON1 genotype was detected in Ontario in 2010 and subsequently reported in several countries. The objective of the present study was to investigate for the first time the RSV epidemiology and genotype diversity in France between 2010 and 2014. All respiratory samples received from patients with influenza-like illness or respiratory tract infection were screened for RSV infection by RT-PCR. The results were stratified according to winter season. Among the RSV-positive cases, 117 samples were further investigated for phylogenetic analysis out of 150 randomly selected for sequencing. Among the 20,359 cases screened, 14% of the cases were RSV-positive. RSV-A was predominant during the four winter seasons. The first ON1 variant was detected during the 2010-2011 winter and reached 85% of all RSV-A-positive cases in 2013-2014. Most RSV-B was classified as BA9 and BA10 genotypes but a new genotype (BA-Ly) was described. As reported in different countries, ON1 variants were firstly detected in 2011 and became the predominant RSV-A genotype in Lyon. Among...Continue Reading

Citations

Oct 30, 2018·Expert Review of Clinical Immunology·Syed-Rehan A HussainMitchell H Grayson
Oct 26, 2018·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·M JeannoëlJean Sebastien Casalegno
May 30, 2019·Medicina·Daifullah Al AboudAhmed S Abdel-Moneim
Jul 14, 2019·BMC Infectious Diseases·Andrea StrengJohannes G Liese
Aug 7, 2020·Journal of Medical Microbiology·Amira JerbiAbdelhalim Trabelsi
Aug 12, 2020·Journal of Medical Virology·Neli KorsunPenka Perenovska
Feb 14, 2021·BMC Geriatrics·Yohan HababouMarie-Anne Rameix-Welti
Feb 12, 2021·Scientific Reports·Juan C Muñoz-EscalanteDaniel E Noyola
Apr 19, 2021·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Amary FallNdongo Dia
Jul 24, 2021·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·Jean-Sebastien CasalegnoYves Gillet
Apr 30, 2020·Intervirology·Katerina TsergouliAnna Papa

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